Evidence map›Paper›PMID 40982530›Full record

ArticlePloS one2025

Mapping unconventional Leishmania in human and animal leishmaniasis: A scoping review protocol on pathogen diversity, geographic distribution and knowledge gaps.

Denis Sereno, Tahar Kernif, Renato Leon, Kholoud Kahime, Souad Guernaoui, Chaymaa Harkat, Mario J Grijalva, Omar Hamarsheh, Anita G Villacis, Bachir Medrouh and 4 more

Abstract read
In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Denis SerenoUMR177 Intertryp, Institut de Recherche pour le Développement, CIRAD, University of Montpellier, Montpellier, France.ORCID https://orcid.org/0000-0002-0034-9291
Tahar KernifLaboratory of Parasitic Eco-Epidemiology and Population Genetics, Pasteur Institute of Algeria, Dely-Brahim, Algiers, Algeria.
Renato LeonMedical Entomology and Tropical Medicine Laboratory LEMMT, School of Biological and Environmental Sciences, Universidad San Francisco de Quito, Quito, Ecuador.
Kholoud KahimeSAEDD Laboratory, School of Technology Essaouira, Cadi Ayyad University of Marrakesh, Morocco.
Souad GuernaouiBiotechnology, Conservation and Valorisation of Natural Resources laboratory, Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, Fez, Morocco.
Chaymaa HarkatSAEDD Laboratory, School of Technology Essaouira, Cadi Ayyad University of Marrakesh, Morocco.
Mario J GrijalvaInfectious and Tropical Disease Institute, Biomedical Sciences Department, Heritage College of Osteopathic Medicine, Athens, Ohio, United States of America.
Omar HamarshehDepartment of Life Sciences, College of Science & Technology, Al-Quds University, Jerusalem, Palestine.
Anita G VillacisCentro de Investigación para la Salud en América Latina, Facultad de Ciencias Exactas, Naturales y Ambientales, Pontificia Universidad Católica del Ecuador, Quito, Ecuador.
Bachir MedrouhResearch Centre for Agropastoralism, Djelfa, Algeria.
Thiago Vasconcelos Dos SantosParasitology Department, Instituto Evandro Chagas, Ministry of Health, Ananindeua, Brazil.
Razika BeniklefLaboratory of Parasitic Eco-Epidemiology and Population Genetics, Pasteur Institute of Algeria, Dely-Brahim, Algiers, Algeria.
Naouel EddaikraLaboratory of Parasitic Eco-Epidemiology and Population Genetics, Pasteur Institute of Algeria, Dely-Brahim, Algiers, Algeria.
Phlippe HolzmullerUMR177 Intertryp, Institut de Recherche pour le Développement, CIRAD, University of Montpellier, Montpellier, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionLeishmaniases are a vector-borne parasitic diseases with diverse clinical manifestations involving multiple Leishmania species and animal hosts. While most leishmaniasis cases are caused by a few well characterized Leishmania species, reports describe infections by unconventional or emerging Leishmania taxa, atypical clinical presentations from classical species, and occurrences of atypical Leishmania in animal hosts. These underrecognized infections present diagnostic and therapeutic challenges and are rarely reflected in surveillance systems or clinical guidelines. A systematic mapping of this evolving landscape is needed to guide future diagnostics, policy, and research priorities. METHODS AND ANALYSIS: Following the Joanna Briggs Institute (JBI) methodology and PRISMA-ScR guidelines, we will search PubMed, Embase, Cochrane Library (CENTRAL), PROSPERO, Web of Science, and Global Index Medicus, as well as relevant grey literature. Eligible studies will include human cases with clinical presentations that diverge from those typically associated with well-characterized Leishmania species, reports involving unconventional or emerging Leishmania species, and animal cases of veterinary relevance caused by non-classical species, regardless of study design. Dual independent screening of records and data extraction using a standardized charting form will be conducted. Discrepancies between reviewers will be resolved by consensus. Data will be summarized descriptively through tables, figures, and thematic synthesis. Research gaps will be identified to inform future studies and public health strategies. DISSEMINATION: This review will use data from published sources and findings will be disseminated through publication in a peer-reviewed journal, presentations at scientific conferences, and sharing with relevant stakeholders. The results are intended to inform clinicians, researchers, and policymakers about the evolving landscape of leishmaniasis and to highlight priorities for future research and surveillance.

Indexed as

LeishmaniaLeishmaniasisAnimalsHumansScoping Reviews as Topic

Identifiers

PMID40982530
PMCPMC12453221

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.