Evidence map›Paper›PMID 40982467›Full record

ArticlePLoS biology2025

Gut fungal profiles reveal phylosymbiosis and codiversification across humans and nonhuman primates.

Emily P Van Syoc, Andres Gomez, Emily R Davenport, Seth R Bordenstein

Abstract read
In one paragraph

Article in PLoS biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Yeasts in the gastrointestinal tract.FEMS yeast research · 2026
    Review
  2. Strengths and limitations ofGut microbes reports · 2026
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Emily P Van SyocOne Health Microbiome Center, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, Pennsylvania, United States of America.ORCID 0000-0002-9984-534X
Andres GomezDepartment of Animal Science, University of Minnesota Twin Cities, Minneapolis, Minnesota, United States of America.
Emily R DavenportOne Health Microbiome Center, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, Pennsylvania, United States of America.
Seth R BordensteinOne Health Microbiome Center, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, Pennsylvania, United States of America.ORCID 0000-0001-7346-0954

Funding

The genetic, symbiotic, and evolutionary bases of the human gut mycobiomeF32DK141228 · NIDDK · PENNSYLVANIA STATE UNIVERSITY, THE · PI VAN SYOC, EMILY P · 2025 to 2025
$35k
NIDDK NIH HHS F32 DK141228
6 · The paper itself

Abstract

Fungi in the gut microbiome, collectively known as the mycobiome, are a prevalent yet neglected component of the human holobiont. A major question in the study of gut microbial communities is whether fungi exhibit eco-evolutionary patterns that are consistent with partner fidelity and long-term associations. We compared gut fungal profiles across natural populations of humans and nonhuman primates and identified significant degrees of primate-mycobiome phylosymbiosis as well as human-enriched fungal taxa. Notably, subsets of fungi are cophylogenetic and exhibit cospeciation patterns in hominids. These findings cautiously originate a new view on the eco-evolutionary potential that can shape the composition of human and primate gut mycobiomes.

Indexed as

FungiGastrointestinal MicrobiomeMycobiomePrimatesSymbiosisAnimalsBiological EvolutionHumansPhylogeny

Identifiers

PMID40982467
PMCPMC12453195

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.