ArticlePloS one2025
Surface protein glycosylation conserved in the human pathogen Mycoplasma genitalium and retained in the synthetic organism JCVI-Syn3A.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Survival strategies of mycoplasmas: the critical role of post-translational modifications.Frontiers in cellular and infection microbiology · 2025Review
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5 authors.
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Abstract
Protein glycosylation has been reported in all forms of life. The genus Mycoplasma is composed of highly genome-streamlined bacterial symbionts, making them model organisms for investigating minimal genome concepts. Previous work from our group showed mycoplasmas scavenge hexoses from exogenous oligosaccharides to glycosylate surface proteins at serine, threonine, asparagine, and glutamine residues without utilizing a consensus sequence as seen in canonical glycosylation systems. We report here that this surface protein hexosylation system is conserved in Mycoplasma genitalium, a human urogenital pathogen with a 580-kbp genome that can be cultured axenically. We also report this modification is found in the ruminant pathogen Mycoplasma mycoides subsp. capri and is conserved in JCVI-Syn3A, a nonpathogenic mycoplasma with a synthetic minimal M. mycoides genome containing genes that are essential for survival and robust growth under axenic culture conditions. In contrast to known glycoproteins, we have detected evidence of glycosylation of aspartic acid and glutamic acid residues, which expands the pool of potential glycosyl acceptors in bacteria to include the acidic amino acids.
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