ReviewPhysiology (Bethesda, Md.)2026
The Heart-Brain Axis in the Context of Cardiovascular Disease.
Review in Physiology (Bethesda, Md.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed.
- How organs react under fasting or glucose-insulin status: a self-controlled study usingEuropean journal of nuclear medicine and molecular imaging · 2026Article
- Neural-immune-cardiovascular axis: from mechanistic crosstalk to therapeutic targets in cardiovascular disease.Frontiers in immunology · 2026Review
- Immunometabolic regulation of cardiac macrophages in heart failure with preserved ejection fraction.Frontiers in immunology · 2026Review
- Research hotspots and trend of the heart-brain axis by MRI: a bibliometric analysis.Frontiers in cardiovascular medicine · 2026Article
- The hierarchical stratum response system of organism to microgravity during spaceflight.Military Medical Research · 2026Review
- Heart-brain axis pathophysiological understanding and clinical impact.Frontiers in cardiovascular medicine · 2026Review
- Artificial intelligence in neurocardiology: decoding brain-heart network interactions for clinical and translational insights.Frontiers in neuroscience · 2026Review
- Association of life's essential 8 with depressive symptoms in US cardiovascular disease survivors: a cross-sectional analysis from NHANES 2007-2018.BMC psychology · 2025Article
- Autonomic neurotransmission in cardiovascular regulation and pathophysiology.Frontiers in neuroscience · 2025Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The heart-brain axis forms an important physiological network, which is increasingly gaining recognition due to its involvement in cardiac function under steady-state conditions and pathological modifications of the heart in cardiovascular disease. Neurological disorders are known to affect cardiac function by propagating structural alterations in the heart. On the other hand, cardiovascular events have detrimental effects on the central nervous system affecting several brain regions, such as the hippocampus, which is important for cognition. Several anatomical regions of the brain, such as cortical and subcortical forebrain structures, regulate cardiovascular functions via the autonomic nervous system. The sympathetic and parasympathetic nervous systems, which are parts of the autonomic nervous system, play a crucial role in cardiovascular health. Cardiovascular disease, such as myocardial infarction (MI), activates the sympathetic nervous system, leading to exaggerated cardiac remodeling and subsequent arrhythmias. MI also alters afferent sensory neurons affecting nociceptive neurotransmission. This review focuses on the significance of the heart-brain axis and summarizes recent studies in this arena.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.