ArticleThe Journal of general virology2025
Pyruvate kinase M2 modulates Japanese encephalitis virus replication in neuronal cells.
Article in The Journal of general virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Japanese encephalitis is a neuroinflammatory condition caused by the Japanese encephalitis virus (JEV). Pyruvate kinase muscle isozyme M2 (PKM2) is a key modulator of glucose metabolism. The role of PKM2 in the autoimmune response and inflammation is now increasingly being acknowledged. However, its role in modulating virus replication has not been explored. In the current study, we have explored the role of PKM2 in JEV replication. Our results show that endogenous PKM2 expression is significantly upregulated in JEV-infected mouse neuroblastoma cells. Moreover, overexpression and knockdown studies substantiate the negative effect of PKM2 on JEV replication. Additionally, JEV infection induced signal transducers and activators of transcription 3 (STAT3) activation in the infected neuronal cells. Overexpression of PKM2 enhanced STAT3 activation, while its downregulation reduced STAT3 activation in the JEV-infected neuronal cells. The results suggested that the overexpression of PKM2 exhibited elevated levels of TNF-
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