Evidence map›Paper›PMID 40982229›Full record

SynthesisHepatology communications2025

Psychosocial therapy improves outcomes for alcohol use disorder in people with chronic liver disease: A systematic review and meta-analysis.

Christopher H Sollenberger, Huai-En R Chang, Jonathan Lim, Mohammed Rifat Shaik, Hanna Blaney, Vaishnavi Mathur, Nancy Terry, Jeremy W Luk, Nancy Diazgranados, Christine C Hsu

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Hepatology communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Christopher H SollenbergerLiver Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA.ORCID 0000-0001-9091-5818
Huai-En R ChangLiver Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA.
Jonathan LimLiver Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA.
Mohammed Rifat ShaikDepartment of Medicine, University of Maryland Medical Center Midtown Campus, Baltimore, Maryland, USA.
Hanna BlaneyDigestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA.ORCID 0000-0003-4919-9519
Vaishnavi MathurLiver Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA.
Nancy TerryNational Institutes of Health Library, Bethesda, Maryland, USA.
Jeremy W LukOffice of the Clinical Director, National Institute of Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA.ORCID 0000-0002-9061-1555
Nancy DiazgranadosOffice of the Clinical Director, National Institute of Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA.ORCID 0000-0002-7415-8455
Christine C HsuLiver Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA.ORCID 0000-0001-8779-9442

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPsychosocial interventions are effective for alcohol use disorder (AUD), but their impact on patients with chronic liver disease and AUD remains unclear. This systematic review and meta-analysis evaluated the effectiveness of psychosocial therapies in preventing return-to-drinking and promoting abstinence among this population. METHODS AND

resultsThe protocol (CRD42024527757) was registered in Prospero. We included studies involving adults (≥18 y) with chronic liver disease and AUD or harmful alcohol use receiving psychosocial interventions. Databases searched were PubMed, Embase, Cochrane CENTRAL, and APA PsycInfo. Outcomes assessed were return-to-drinking and abstinence. Risk of bias was evaluated using RoB2 for randomized controlled trials (RCTs) and ROBINS-I for non-RCTs. Meta-analysis was performed using random effects (Knap-Hartung adjustment) and fixed effects (inverse variance) models. Funding was provided by the intramural research program at the National Institute of Diabetes and Digestive and Kidney Diseases. Of 2240 studies reviewed, 20 met the inclusion criteria. Meta-analysis of 7 non-RCTs (n=767) demonstrated a 48% reduction in return-to-drinking risk (relative risk [RR]=0.52, 95% CI: 0.28-0.99, p=0.048) with significant heterogeneity (I2=74%; p=0.006). Subgroup analyses showed greater return-to-drinking reduction in multidisciplinary care (RR=0.40, 95% CI: 0.31-0.52) and recipients of liver transplant (RR=0.40, 95% CI: 0.27-0.58). Four RCTs found no significant return-to-drinking reduction (RR=0.99, 95% CI: 0.45-2.16, p=0.96). Abstinence was not significantly improved in either RCTs or non-RCTs, with moderate- to low-quality evidence.

conclusionsPsychosocial therapy reduces return-to-drinking risk in chronic liver disease with AUD, particularly within multidisciplinary teams or transplant populations, but findings are tempered by scarce RCT evidence. Future RCTs should evaluate multidisciplinary interventions in transplant populations.

Indexed as

Alcohol AbstinenceAlcoholismLiver DiseasesPsychosocial InterventionChronic DiseaseHumansTreatment Outcomeabstinencedigital healthliver transplantmultidisciplinary treatmentreturn-to-drinking prevention

Identifiers

PMID40982229
PMCPMC12456490

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.