ArticleAnnals of surgical oncology2026
Elevated Proportion of Tumor-Infiltrating Natural Killer Cells Predicts Improved Survival in Peritoneal Mesothelioma: A Single-Center Study of 109 Cases.
Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- 3D chemotaxis chip for investigating natural killer cell migration mechanisms.Frontiers in immunology · 2026Article
- Oligometastatic Gastric Cancer: Novel Considerations for Personalized Approach.Journal of gastrointestinal cancer · 2025Review
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Authors and funding
11 authors.
Funding
Abstract
backgroundPeritoneal mesothelioma (PeM) is an aggressive malignancy with a dismal prognosis and limited therapeutic options. Tumor-infiltrating natural killer (NK) cells play a pivotal role in anti-tumor immunity, yet their clinical significance in PeM remains unclear. This study aimed to investigate the correlation between NK cell infiltration levels and the main clinicopathologic characteristics and prognosis in PeM.
methodsThe study collected 109 postoperative specimens from PeM patients after cytoreductive surgery. Immunohistochemical staining was performed, and NK cell infiltration was quantified using QuPath-0.3.2 software. Uni- and multivariate analyses were performed to assess correlations between NK infiltration levels and clinicopathologic parameters.
resultsThe 109 PeM patients in the study included 52 males (47.7%) and 57 females (52.3%) with a median age of 54 years (range, 25-72 years). Levels of NK infiltration were found to be low in 54 (49.5%) cases and high in 55 (50.5%) cases. Univariate analysis showed that a high NK infiltration level was negatively associated with the following five clinicopathologic factors: preoperative carbohydrate antigen (CA) 125 level, completeness of cytoreduction (CC), bleeding, red blood cell (RBC) transfusion, and ascites (all P < 0.05). Additionally. survival analysis demonstrated that a high NK infiltration level was associated with a better prognosis.
conclusionTumor-infiltrating NK cells may serve as prognostic biomarkers and guide personalized treatment strategies for PeM patients.
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