Evidence map›Paper›PMID 40982032›Full record

SynthesisRheumatology international2025

Diagnostic accuracy of anti-carbamylated protein antibodies in rheumatoid arthritis: a systematic review and meta-analysis.

Pannathorn Nakaphan, Patavee Pajareya, Priabprat Jansem, Somkiat Phutinart, Nattanicha Chaisrimaneepan, Tanattida Kassels, Noppachai Siranart

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Rheumatology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pannathorn NakaphanDepartment of Internal Medicine, Weiss Memorial Hospital, 4646 N Marine Dr, Chicago, IL, 60640, USA. pannathorn0769@gmail.com.ORCID http://orcid.org/0009-0006-5137-5998
Patavee Pajareya *Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. patavee.pd@gmail.com.ORCID http://orcid.org/0009-0001-5647-346X
Priabprat JansemDepartment of Psychiatry, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.ORCID http://orcid.org/0009-0000-1598-6763
Somkiat PhutinartFaculty of Medicine, Chulalongkorn University, Bangkok, Thailand.ORCID http://orcid.org/0000-0002-4189-3621
Nattanicha ChaisrimaneepanDepartment of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA.ORCID http://orcid.org/0000-0002-3183-7853
Tanattida KasselsFaculty of Medicine, Chulalongkorn University, Bangkok, Thailand.ORCID http://orcid.org/0009-0009-8624-2759
Noppachai SiranartFaculty of Medicine, Chulalongkorn University, Bangkok, Thailand.ORCID http://orcid.org/0000-0003-3315-6020

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anti-carbamylated protein (anti-CarP) antibodies have emerged as novel serologic markers in rheumatoid arthritis (RA). This meta-analysis aimed to assess the diagnostic accuracy of anti-CarP antibodies in RA patients.A systematic Literature search was conducted through April 2025. Primary outcome was diagnostic accuracy of anti-CarP antibodies compared to healthy controls; secondary outcomes included subgroup analyses by anti-citrullinated protein antibodies (ACPA) status.Thirty-six studies (7431 RA patients; 3347 healthy controls) were included. Most used in-house ELISA platforms. Overall, Anti-CarP antibodies showed high specificity but Limited sensitivity in detecting RA with pooled sensitivity and specificity of 44% (95% CI: 39-49%, I²=91.5%) and 96% (95%CI: 94-97%, I²=65.5%), respectively. The pooled diagnostic odds ratio was 14.72 (95%CI: 10.75-20.15, I

Indexed as

Arthritis, RheumatoidAutoantibodiesAnti-Citrullinated Protein AntibodiesBiomarkersHumansProtein CarbamylationSensitivity and SpecificityAnti-Citrullinated Protein AntibodiesAutoantibodiesBiomarkersAntibodiesArthritis, rheumatoidDiagnosisMeta-AnalysisProtein carbamylationSensitivity and specificity

Identifiers

PMID40982032

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.