Evidence map›Paper›PMID 40982000›Full record

ArticleAnnals of hematology2025

USP7 mutations are associated with adverse outcomes in pediatric T cell acute lymphoblastic leukemia and lymphoma.

Jun Li, Yuan Yuan, Feng-Feng Niu, Ying Wang, Wei Lin, Rui-Dong Zhang, Ling Jin, Yan-Long Duan, Chao Gao

Abstract read
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In one paragraph

Article in Annals of hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jun LiDepartment of Clinical Laboratory Center, Key Laboratory of Major Diseases in Children Ministry of Education, Beijing Children's Hospital Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Yuan YuanDepartment of Leukemia, Key Laboratory of Major Diseases in Children Ministry of Education, Beijing Children's Hospital Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Feng-Feng NiuDepartment of Clinical Laboratory Center, Key Laboratory of Major Diseases in Children Ministry of Education, Beijing Children's Hospital Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Ying WangDepartment of Clinical Laboratory Center, Key Laboratory of Major Diseases in Children Ministry of Education, Beijing Children's Hospital Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Wei LinDepartment of Leukemia, Key Laboratory of Major Diseases in Children Ministry of Education, Beijing Children's Hospital Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Rui-Dong ZhangDepartment of Leukemia, Key Laboratory of Major Diseases in Children Ministry of Education, Beijing Children's Hospital Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Ling JinDepartment of Oncology, Key Laboratory of Major Diseases in Children Ministry of Education, Beijing Children's Hospital Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Yan-Long DuanDepartment of Oncology, Key Laboratory of Major Diseases in Children Ministry of Education, Beijing Children's Hospital Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Chao GaoDepartment of Clinical Laboratory Center, Key Laboratory of Major Diseases in Children Ministry of Education, Beijing Children's Hospital Capital Medical University, National Center for Children's Health, Beijing, 100045, China. gaochao@bch.com.cn.

Funding

National Natural Science Foundation of China 82170150Natural Science Foundation of Beijing Municipality 7192066
6 · The paper itself

Abstract

USP7 alterations in pediatric T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/LBL) remains incompletely understood. We investigated the clinical features and long-term outcomes associated with USP7 mutations in a cohort of 313 pediatric T-ALL/LBL patients. USP7 and NOTCH1 mutations were detected by Sanger sequencing and their association with prognosis were analyzed. Cox regression and nomogram models were used to evaluate prognostic importance. We identified 12 patients with USP7 heterozygous mutations (10 T-ALL, 2 T-LBL) with older age and higher proportion of not remission at day 15 morphological evaluation. Patients with USP7 mutation showed significantly worse event-free survival (EFS) and overall survival (OS) compared to wild-type cases, both in T-ALL and combined T-ALL/LBL cohorts. Concurrent analysis of USP7 and NOTCH1 mutations revealed USP7

Indexed as

MutationPrecursor T-Cell Lymphoblastic Leukemia-LymphomaUbiquitin-Specific Peptidase 7AdolescentChildChild, PreschoolDisease-Free SurvivalFemaleHumansInfantMalePrognosisReceptor, Notch1NOTCH1 protein, humanReceptor, Notch1Ubiquitin-Specific Peptidase 7USP7 protein, humanClinical studyMolecular diagnosisPediatricsPrognostic factorT-ALLT-LBL

Identifiers

PMID40982000
PMCPMC12619799

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.