Evidence map›Paper›PMID 40981818›Full record

ArticleJournal of the Optical Society of America. A, Optics, image science, and vision2025

Spectroscopic analysis of volumetric OCT data for the automated measurement of scatterer size.

Erin C O'Kane, Wan Wang, Robert E Highland, David A Miller, Adam Wax

Abstract read
In one paragraph

Article in Journal of the Optical Society of America. A, Optics, image science, and vision, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Erin C O'Kane
Wan Wang
Robert E Highland
David A Miller
Adam Wax

Funding

Retinal Light Scattering Measurements as a Clinical Biomarker of Alzheimer's DiseaseR01AG072732 · NIA · DUKE UNIVERSITY · PI Adam Wax · 2022 to 2026
$2.4M
NIA NIH HHS R01 AG072732
6 · The paper itself

Abstract

Spectroscopic optical coherence tomography enables an accurate estimation of scatterer size by computing the correlation distance (CD) function. For calibration and accuracy verification, polystyrene spheres are commonly used as size standards. However, anomalies have been observed when using the CD function to analyze spherical scatterers, which we link to multiple scattering. We have developed a robust, automated algorithm to calculate the size of hundreds of scatterers within a volumetric OCT image while accounting for the effects of multiple scattering. We measured 5.1, 7.7, and 11.3 µm polystyrene beads suspended in collagen hydrogel, agarose, and polydimethylsiloxane, which resulted in average diameters in agreement with the theoretical size to within ±

Identifiers

PMID40981818
PMCPMC12859759

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.