Evidence map›Paper›PMID 40981487›Full record

ArticlemSystems2025

Gut microbiome mediates the associations between lifestyle factors and risk of colorectal high-risk adenoma: results from a population-based cohort study.

Kai Song, Jiahui Luo, Yuhan Zhang, Dong Wu, Hongda Chen, Min Dai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSystems, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kai SongCenter for Prevention and Early Intervention, National Infrastructures for Translational Medicine, Institute of Clinical Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.ORCID 0000-0003-4459-7059
Jiahui LuoCenter for Prevention and Early Intervention, National Infrastructures for Translational Medicine, Institute of Clinical Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Yuhan ZhangCenter for Clinical and Epidemiologic Research, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China.
Dong WuDepartment of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.ORCID 0000-0001-9430-9874
Hongda ChenCenter for Prevention and Early Intervention, National Infrastructures for Translational Medicine, Institute of Clinical Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.ORCID 0000-0001-6171-1162
Min DaiDepartment of Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lifestyle factors exert influence on the risk of colorectal cancer (CRC) and its precursors. However, the interaction between gut microbiota and lifestyle factors concerning colorectal high-risk adenomas (HRAs), as well as the specific microbial taxa implicated, remains underexplored. Here, we aimed to investigate the impact of common lifestyle factors on HRAs and to explore the potential mediating roles of gut microbiota in these effects. A total of 3,827 participants were enrolled from our multicenter CRC screening cohort. Lifestyle factors over the 12 months preceding enrollment were assessed via questionnaires. Fecal samples were collected upon enrollment and analyzed using 16S rRNA sequencing. Multivariate analyses were used to identify lifestyle-related risk factors for HRA, followed by the application of the multivariate association with linear models (MaAsLin2) to explore associations between microbiota and lifestyle risk factors, with causal mediation analysis employed to evaluate the gut microbiota's mediating effect between lifestyle factors and HRA risk. A total of 272 patients with HRA and 1,253 controls were included. Independent risk factors for HRA were identified as high body mass index, number of pack-years smoked >30, alcohol consumption >4 units/week. These lifestyle factors were significantly associated with the relative abundance of various microbial genera. Notably, genus

Indexed as

AdenomaColorectal NeoplasmsGastrointestinal MicrobiomeLife StyleAgedAlcohol DrinkingCohort StudiesFecesFemaleHumansMaleMiddle AgedRisk FactorsRNA, Ribosomal, 16SRNA, Ribosomal, 16Scolorectumgut microbiotalifestylemediationprecancerous lesions

Identifiers

PMID40981487
PMCPMC12542775

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.