ArticleMicrobiology spectrum2025
Rapid direct disk diffusion testing for antibiotic resistance in urinary tract infections: a bacterial concentration-adjusted approach.
Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
4 authors.
Funding
Abstract
Urinary tract infections are among the most prevalent bacterial infections worldwide, typically diagnosed using clinical symptoms, dipstick tests, and laboratory methods requiring standardized bacterial suspensions for antibiotic susceptibility testing (AST). This study evaluated two rapid disk diffusion methods for urine samples that incorporate bacterial concentration into the analysis, eliminating the need for standardized suspensions. The threshold-adapted approach compares inhibition zones to concentration-specific breakpoints derived from reference strains, while the regression-based method transforms inhibition zones at various concentrations into predicted standard (0.5 McFarland) values using a linear model. In both methods, urine and antibiotic disks are applied to one agar plate for disk diffusion, while a separate plate determines bacterial concentration, enables isolation, and supports matrix-assisted laser desorption/ionization-time-of-flight (MALDI-TOF) analysis. This simultaneous processing reduces diagnostic time by 18-24 hours. The approaches were compared with traditional disk diffusion testing using defined bacterial suspensions, reference strains, and clinical urine samples. In trials using defined suspensions from 0.5 McFarland to 10
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