Evidence map›Paper›PMID 40981434›Full record

ReviewJournal of virology2025

Human metapneumovirus: understanding the molecular mechanisms and pathology of infection.

Chase J Heim, Bernadette G van den Hoogen, Rebecca E Dutch

Abstract readReview
In one paragraph

Review in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Twenty-five years of human metapneumovirus research.Clinical microbiology reviews · 2026
    Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Molecular Evolution of theMicroorganisms · 2026
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Chase J HeimDepartment of Molecular and Cellular Biochemistry, University of Kentucky, College of Medicine, Lexington, Kentucky, USA.ORCID 0009-0005-7561-1855
Bernadette G van den HoogenDepartment of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands.ORCID 0000-0003-1996-8559
Rebecca E DutchDepartment of Molecular and Cellular Biochemistry, University of Kentucky, College of Medicine, Lexington, Kentucky, USA.ORCID 0000-0002-5220-8247

Funding

HMPV/RSV co-infection: effects on replication and viral spreadR21AI178798 · NIAID · UNIVERSITY OF KENTUCKY · PI DUTCH, REBECCA E. · 2023 to 2024
$413k
National Institute of Allergy and Infectious Diseases 5R21AI178798NIAID NIH HHS R21 AI178798
6 · The paper itself

Abstract

Human metapneumovirus (HMPV) is a common and globally prevalent respiratory virus that can cause clinical symptoms ranging from mild respiratory illness to severe bronchiolitis and pneumonia, with substantial morbidity and mortality. HMPV accounts for a substantial health care and economic burden, with high hospitalization rates. Consequently, there is an urgent need for effective preventive and therapeutic interventions. The development of these interventions requires comprehensive knowledge of the virus's biology, including characteristics, epidemiology, evolution, virus-host interactions, and host immune responses. Despite being discovered nearly 25 years ago, HMPV has remained relatively underrecognized, resulting in limited awareness of its true impact and delays in the development of treatment options. Recent studies have demonstrated the emergence of novel genotypes and provided more insight into viral replication, spread, and host immune responses. In this review, we highlight the clinical significance of HMPV and explore the molecular mechanisms the virus employs throughout the course of an infection.

Indexed as

MetapneumovirusParamyxoviridae InfectionsRespiratory Tract InfectionsHost-Pathogen InteractionsHumansVirus ReplicationHMPVpneumovirus

Identifiers

PMID40981434
PMCPMC12548460

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.