Evidence map›Paper›PMID 40981418›Full record

ArticlemBio2025

Lactate metabolism is exploited by

Forrest Jessop, Eric Borhnsen, Benjamin Schwarz, Kaitlin A Stromberg, Molly Miltko, Tyler Jones, Tara Wehrly, Catharine M Bosio

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Modulation of macrophage survival duringFrontiers in cellular and infection microbiology · 2026
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Forrest JessopImmunity to Pulmonary Pathogens Section, Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana, USA.ORCID 0009-0001-5163-1457
Eric BorhnsenResearch Technologies Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana, USA.
Benjamin SchwarzResearch Technologies Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana, USA.
Kaitlin A StrombergImmunity to Pulmonary Pathogens Section, Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana, USA.
Molly MiltkoImmunity to Pulmonary Pathogens Section, Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana, USA.
Tyler JonesImmunity to Pulmonary Pathogens Section, Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana, USA.
Tara WehrlyImmunity to Pulmonary Pathogens Section, Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana, USA.
Catharine M BosioImmunity to Pulmonary Pathogens Section, Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana, USA.ORCID 0000-0001-9039-6341

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intracellular pathogens manipulate host metabolic systems to establish a replicative niche and evade immune responses. However, mechanisms by which metabolism can be altered for successful infection remain poorly understood. Here, we identify a metabolism-based strategy used by the intracellular pathogen

Indexed as

Bacterial CapsulesFrancisella tularensisLactic AcidMacrophage ActivationMacrophagesO AntigensAnimalsCell DeathHost-Pathogen InteractionsHumansMiceMitochondriaMonocarboxylic Acid TransportersTularemiaLactic AcidMonocarboxylic Acid TransportersO Antigenscapsuleintracellular bacterialactatemacrophagesmetabolismmitochondria

Identifiers

PMID40981418
PMCPMC12607874

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.