A systems-level insight into PHB-driven metabolic adaptation orchestrated by the PHB-binding transcriptional regulator AniA (PhaR).

Antonio Lagares, Elizaveta Krol, Tina Jühling, Timo Glatter, Anke Becker

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Article in mSystems, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Antonio LagaresCenter for Synthetic Microbiology (SYNMIKRO) and Department of Biology, Philipps-Universität Marburg, Marburg, Germany.ORCID 0000-0001-8557-7500

Elizaveta KrolCenter for Synthetic Microbiology (SYNMIKRO) and Department of Biology, Philipps-Universität Marburg, Marburg, Germany.

Tina JühlingCenter for Synthetic Microbiology (SYNMIKRO) and Department of Biology, Philipps-Universität Marburg, Marburg, Germany.

Timo GlatterMass Spectrometry and Proteomics Facility, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany.

Anke BeckerCenter for Synthetic Microbiology (SYNMIKRO) and Department of Biology, Philipps-Universität Marburg, Marburg, Germany.ORCID 0000-0003-4561-9184

Funding

Alexander von Humboldt-Stiftung postdoctoral fellowshipDeutsche Forschungsgemeinschaft BE 2121/9-1

6 · The paper itself

Abstract

Poly(3-hydroxybutyrate) (PHB) is a carbon and energy storage polymer, whose accumulation under nutrient imbalances with excess carbon is common in bacteria. PhaR is a conserved transcriptional regulator that associates with PHB granules in several species. Although its role in modulating PHB storage and metabolism has been extensively studied across the bacterial phylogeny, a systems-level view of PhaR's dual function as a metabolic sensor and regulator is lacking. Here, we integrated co-expression network analysis with proteome profiling across multiple mutant backgrounds (lack of PhaR [AniA] and/or PHB synthesis) in the free-living state of the PHB-accumulating α-proteobacterial root nodule symbiont

Indexed as

Bacterial ProteinsHydroxybutyratesPolyestersSinorhizobium melilotiTranscription FactorsGene Expression Regulation, BacterialPolyhydroxybutyratesProhibitinsBacterial ProteinsHydroxybutyratespoly-beta-hydroxybutyratePolyestersPolyhydroxybutyratesProhibitinsTranscription FactorsAlphaproteobacteriaAniA reguloncarbon metabolismEnsifermetabolic sensorPhaR regulonpolyhydroxybutyrateSinorhizobiumtranscription regulator

Identifiers

PMID40981414

DOI10.1128/msystems.00760-25

PMCPMC12542648

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.