Evidence map›Paper›PMID 40981269›Full record

ReviewJournal of developmental biology2025

Signaling Pathways in Human Blastocyst Development: From Molecular Mechanisms to In Vitro Optimization.

Yan Jiao, Jiapeng Liu, Congge Li, Yuexin Hu, Sanjun Zhao

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yan JiaoSchool of Life Sciences, Yunnan Normal University, Kunming 650500, China.ORCID 0009-0004-0450-9143
Jiapeng LiuMedical School, Kunming University of Science and Technology, Kunming 650500, China.
Congge LiState Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming 650500, China.
Yuexin HuSchool of Humanities and Management, Kunming Medical University, Kunming 650500, China.
Sanjun ZhaoSchool of Life Sciences, Yunnan Normal University, Kunming 650500, China.

Funding

the Joint Special Funds for the Department of Science and Technology of Yunnan Province‑Kunming Medical University;Scientifc Research Fund of Yunnan Provincial Education Commission 202301AY070001-055;2023J0233
6 · The paper itself

Abstract

In recent years, assisted reproductive technology (ART) has developed rapidly with the delay in reproductive age and the rise in infertility rates. During ART, blastocyst quality is a key factor affecting the rate of implantation and clinical pregnancy, and blastocyst formation is dependent on the precise regulation of multiple signaling pathways in preimplantation embryo development. In this review, we systematically analyze the molecular mechanisms of the core pathways, including Hippo, Wnt/β-catenin, FGF, Nodal, and BMP, in blastocyst lineage differentiation and morphogenesis, and assess the feasibility of optimizing in vitro culture by targeting key signaling nodes, as well as provide theoretical support for constructing research models of preimplantation embryos.

Indexed as

assisted reproductive technologylineage specificationpreimplantation embryo developmentsignaling pathways

Identifiers

PMID40981269
PMCPMC12452331

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.