ReviewPathophysiology : the official journal of the International Society for Pathophysiology2025
Decreased Heart Rate Variability Is Associated with Increased Fatigue Across Different Medical Populations: A Systematic Review.
Review in Pathophysiology : the official journal of the International Society for Pathophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Individual Patterns of Heart Rate Variability During Prolonged Cognitive Load with Mental Fatigue Induction.Life (Basel, Switzerland) · 2026Article
- Real-Time Fatigue Monitoring Using sEMG and HRV Sensors for Industrial Operators Under Swing Conditions.Sensors (Basel, Switzerland) · 2026Article
- Predicting driver fatigue using HRV measures and machine learning.Frontiers in sports and active living · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundFatigue has been associated with poorer quality of life and increased morbidity in multiple clinical fields. Patients with autonomic dysfunction have been found to experience poorer physiological health, as well as having an increased risk of comorbidity and all-cause mortality. Heart rate variability (HRV) has been documented as a validated tool to assess autonomic function in clinical practice. The aim of this systematic review was to understand the relationship between fatigue and HRV in different medical populations.
methodsA systematic search was conducted in MEDLINE via Web of Science and Scopus.
resultsA total of seventeen articles were identified for inclusion. Patients with Chronic Fatigue Syndrome were the most investigated population (
conclusionsDespite these discrepancies, the reviewed evidence suggests that a rise in sympathetic activity and reduced parasympathetic tone are associated with an increased perception of fatigue in medical populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.