Evidence map›Paper›PMID 40981094›Full record

ArticleArhiv za higijenu rada i toksikologiju2025

Effects of exposure to insecticides on sleep and neurobehavioural functioning in puberty and adolescence: a scoping review.

Patricia Tomac, Adrijana Košćec Bjelajac, Ivana Hromatko, Veda Marija Varnai

Abstract readScoping Review
In one paragraph

Article in Arhiv za higijenu rada i toksikologiju, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Patricia TomacInstitute for Medical Research and Occupational Health, Zagreb, Croatia.ORCID https://orcid.org/0000-0002-3536-853X
Adrijana Košćec BjelajacInstitute for Medical Research and Occupational Health, Zagreb, Croatia.
Ivana HromatkoUniversity of Zagreb Faculty of Humanities and Social Sciences, Zagreb, Croatia.
Veda Marija VarnaiInstitute for Medical Research and Occupational Health, Zagreb, Croatia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Insecticides are pervasive in modern world, with humans being exposed through multiple pathways including dietary intake, occupational exposure, farming activities, residential proximity to crops, and household use. Most commonly used insecticides are neonicotinoids, pyrethroids, organophosphates, and carbamates. Recent evidence suggests that even low-level exposure to these substances may have adverse effects. Adolescence, characterised by intensive maturation processes, is a period of heightened vulnerability to environmental toxicants which may increase the risk of suboptimal developmental outcomes. This review aimed to synthesise the evidence of association between insecticide exposure in childhood/adolescence and sleep and neurobehavioural functioning in children and adolescents aged 8-20 years. Literature search across Web of Science, PubMed, Scopus, and PsycINFO produced 1,492 unique records, of which 48 studies met the inclusion criteria and underwent full-text analysis. Nine of the analysed studies investigated occupational exposure. Most employed cross-sectional design. Insecticide exposure was most often assessed through biomonitoring, questionnaires or interviews, temporal or spatial proximity to crops, and environmental sampling. Occupational exposure studies were primarily conducted in Africa, whereas nonoccupational studies were mostly based in the Americas, Asia, and Europe. Cognitive functioning was the most evaluated aspect of neurobehavioural functioning, while sleep was assessed only in one study. Although the findings are heterogeneous, they suggest that both work-related and residential exposures may affect neurobehaviour and sleep in puberty and adolescence. However, further longitudinal research is needed to clarify causation and also incorporate sleep health and pubertal maturation into the design, both as outcomes and mediators of neurobehavioral effects.

Indexed as

Environmental ExposureInsecticidesPubertySleepAdolescentChildFemaleHumansMaleYoung AdultInsecticidesadolescentiadolescentsbehaviourcarbamatescognitionemocijeemotionskarbamatikognicijakvaliteta spavanjaneonicotinoidsneonikotinoidiorganofosfatiorganophosphatespiretroidiponašanjepubertal developmentpubertalni razvojpyrethroidssleep quality

Identifiers

PMID40981094
PMCPMC12455702

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.