Evidence map›Paper›PMID 40981089›Full record

ArticleArhiv za higijenu rada i toksikologiju2025

Mechanistic insights into the cytotoxic and apoptotic effects of 1-butyl-3-methylimidazolium bromide and 1-butylpyridinium bromide on human cell lines.

Lu Gao, Charles Obinwanne Okoye, Bonaventure Chidi Ezenwanne, Jianxiong Jiang, Guizhu Wu, Lin Yu, Daolin Du, Yonglai Xue

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arhiv za higijenu rada i toksikologiju, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lu GaoJiangsu University School of Environment and Safety Engineering, Biofuels Institute, Zhenjiang, China.
Charles Obinwanne OkoyeJiangsu University School of Environment and Safety Engineering, Biofuels Institute, Zhenjiang, China.
Bonaventure Chidi EzenwanneJiangsu University School of Environment and Safety Engineering, Biofuels Institute, Zhenjiang, China.
Jianxiong JiangJiangsu University School of Environment and Safety Engineering, Biofuels Institute, Zhenjiang, China.
Guizhu WuJiangsu University School of Environment and Safety Engineering, Institute of Environment and Ecology, Zhenjiang, China.
Lin YuTianjin Medical University School of Basic Medical Sciences, Department of Biochemistry and Molecular Biology, Tianjin, China.
Daolin DuJiangsu University School of Environment and Safety Engineering, Institute of Environment and Ecology, Zhenjiang, China.
Yonglai XueJiangsu University School of Environment and Safety Engineering, Institute of Environment and Ecology, Zhenjiang, China.ORCID https://orcid.org/0009-0009-6578-6327

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ionic liquids (ILs) are a novel class of salts with growing industrial applications due to their tunable physicochemical properties. However, their popularity has given rise to concerns about their cytotoxic potential. This study investigates the cytotoxic, apoptotic, and cell cycle effects of two ILs, namely 1-butyl-3-methylimidazolium bromide ([Bmim]Br) and 1-butylpyridinium bromide ([Bpy]Br), on three human cell lines: HeLa (cervical cancer), MCF-7 (breast cancer), and HEK293T (human embryonic kidney). Using real-time cell analysis (RTCA), we determined that the half-maximal inhibition concentrations (IC

Indexed as

Antineoplastic AgentsApoptosisImidazolesIonic LiquidsPyridinium CompoundsCell CycleCell ProliferationHEK293 CellsHeLa CellsHumansMCF-7 Cells1-butyl-3-methylimidazolium chlorideAntineoplastic AgentsImidazolesIonic LiquidsPyridinium Compoundsanti-proliferative effectsantiproliferativno djelovanjeapoptosisapoptozacell cycle arrestcitotoksičnostcytotoxicityHEK293T cellsHEK293T staniceHeLa cellsHeLa staniceionic liquidsionske tekućineMCF-7 cellsMCF-7 stanicezaustavljanje staničnog ciklusa

Identifiers

PMID40981089
PMCPMC12455699

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.