Evidence map›Paper›PMID 40980957›Full record

ReviewJournal of pineal research2025

Melatonin-Producing Microorganisms: A Rising Research Interest in Their Melatonin Biosynthesis and Effects on Crops.

Sang-Mo Kang, Ashim Kumar Das, Da-Sol Lee, Byung-Wook Yun, Marino B Arnao, In-Jung Lee

Abstract readReview
In one paragraph

Review in Journal of pineal research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sang-Mo KangDepartment of Applied Biosciences, Kyungpook National University, Daegu, Republic of Korea.ORCID https://orcid.org/0000-0001-9788-4209
Ashim Kumar DasDepartment of Applied Biosciences, Kyungpook National University, Daegu, Republic of Korea.ORCID https://orcid.org/0000-0001-6012-4812
Da-Sol LeeDepartment of Applied Biosciences, Kyungpook National University, Daegu, Republic of Korea.ORCID https://orcid.org/0009-0005-7045-4619
Byung-Wook YunDepartment of Applied Biosciences, Kyungpook National University, Daegu, Republic of Korea.ORCID https://orcid.org/0000-0002-5451-2365
Marino B ArnaoDepartment of Plant Biology (Plant Physiology), Faculty of Biology, University of Murcia, Murcia, Spain.ORCID https://orcid.org/0000-0001-8517-6889
In-Jung LeeDepartment of Applied Biosciences, Kyungpook National University, Daegu, Republic of Korea.ORCID https://orcid.org/0000-0001-7154-4820

Funding

This study was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (RS-2025-00516246).
6 · The paper itself

Abstract

Melatonin is imperative in animals and plants, contributing to multiple physiological roles, and its microbial production could offer an eco-friendly alternative to synthetic melatonin. However, detecting and characterizing it in microorganisms remains ongoing, and the biosynthesis pathways are still poorly explored. We noted that not all microorganisms possess similar enzymes and substrates for melatonin production. Its biosynthesis pathway is well-characterized in yeast, potentiating its importance in agricultural practices in a melatonin-dependent manner. Intercellular melatonin production in algae and fungi boosts their resilience to oxidative cell death by activating the antioxidant defenses. Few studies on the use of Bacillus sp., Pseudomonas sp., and Enterobacter sp. have shown that these bacteria increase their endogenous melatonin contents, which may exchange with their host plants; thereby, mitigating abiotic stresses by modulating cellular damages, ion exchanges, hormonal levels, and related transcript expressions. Though plant-growth-promoting microbes show promise to enhance crop production, melatonin-producing microorganisms (M-PMs) are limited in identification, and their ecological and biological applications are still underutilized in agriculture. With the compounded benefits from M-PMs, it could be an untapped tool for rhizospheric bioengineering. Therefore, this review delivers comprehensive insights into M-PMs for practicing sustainable agriculture under increased climatic changes.

Indexed as

Crops, AgriculturalMelatoninAgricultureBacillusDinoflagellidaEnterobacterFungiPseudomonasMelatoninalgaeE. colimelatoninphytomelatoninplant‐microbeplant pathogen defenserhizobiomeSaccharomycesstress responses

Identifiers

PMID40980957
PMCPMC12452222

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.