Evidence map›Paper›PMID 40980920›Full record

ArticleAntimicrobial agents and chemotherapy2025

Evolution of beta-lactam resistance causes fitness reductions and several cases of collateral sensitivities in the human pathogen

Sabine Petersen, Margo Diricks, Christian Utpatel, Hinrich Schulenburg, Matthias Merker

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sabine PetersenEvolution of the Resistome, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.
Margo DiricksMolecular and Experimental Mycobacteriology, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.
Christian UtpatelMolecular and Experimental Mycobacteriology, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.
Hinrich SchulenburgEvolutionary Ecology and Genetics, Kiel University, Kiel, Germany.ORCID 0000-0002-1413-913X
Matthias MerkerEvolution of the Resistome, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.ORCID 0000-0003-1386-2331

Funding

German Ministry of Education and Research DZIFGerman Research Foundation EXC 2167German Research Foundation RTG 2501Leibniz Association EvoLUNGMax-Planck Society Fellowship
6 · The paper itself

Abstract

The evolution of antimicrobial-resistant pathogens poses a global health threat, and it is unclear if evolutionary trajectories to resistance lead to predictable phenotypes. We analyzed antimicrobial resistance (AMR) evolution in the human pathogen

Indexed as

Anti-Bacterial Agentsbeta-Lactam Resistancebeta-LactamsHaemophilus influenzaeAmpicillinBacterial Outer Membrane ProteinsBacterial ProteinsCefotaximeCeftriaxoneClarithromycinColistinEvolution, MolecularFluoroquinolonesGenetic FitnessHumansMeropenemAmpicillinAnti-Bacterial AgentsBacterial Outer Membrane ProteinsBacterial Proteinsbeta-LactamsCefotaximeCeftriaxoneClarithromycinColistinFluoroquinolonesMeropenemPenicillin-Binding ProteinsRifampinTetracyclineampicillin resistancecephalosporin resistancecollateral effectsevolution of antimicrobial resistanceHaemophilus influenzae

Identifiers

PMID40980920
PMCPMC12587571

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.