Evidence map›Paper›PMID 40980913›Full record

ArticleAntimicrobial agents and chemotherapy2025

Acquired amphotericin B resistance attributed to a mutated

Lauryn Massic, Laura A Doorley, Sarah J Jones, Irene Richardson, Danielle Denise Siao, Lauren Siao, Philip Dykema, Chi Hua, Emily Schneider, Christina A Cuomo and 7 more

Abstract readCase Reports
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Deciphering the multidrug resistance paradigm inAntimicrobial agents and chemotherapy · 2026
    Review
  5. Comprehensive Insights into Sugar Transporters ofJournal of fungi (Basel, Switzerland) · 2026
    Article
  6. First Report ofJournal of fungi (Basel, Switzerland) · 2025
    Article
  7. Ergosterol-depleted clinical isolates ofbioRxiv : the preprint server for biology · 2025
    Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Lauryn MassicNevada State Public Health Laboratory, Reno, Nevada, USA.ORCID 0009-0006-7245-3182
Laura A DoorleySt Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID 0000-0002-1695-9561
Sarah J JonesSt Jude Children's Research Hospital, Memphis, Tennessee, USA.
Irene RichardsonNevada State Public Health Laboratory, Reno, Nevada, USA.
Danielle Denise SiaoNevada State Public Health Laboratory, Reno, Nevada, USA.
Lauren SiaoNevada State Public Health Laboratory, Reno, Nevada, USA.
Philip DykemaWashington State Department of Health, Olympia, Washington, USA.ORCID 0000-0002-2158-3175
Chi HuaWashington State Department of Health, Olympia, Washington, USA.
Emily SchneiderWashington State Department of Health, Olympia, Washington, USA.
Christina A CuomoBrown University Division of Biology and Medicine, Providence, Rhode Island, USA.
P David RogersSt Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID 0000-0002-4401-0679
Stephanie Van HooserNevada State Public Health Laboratory, Reno, Nevada, USA.
Josie E ParkerCardiff University Schools of Biosciences, Cardiff, Wales, United Kingdom.ORCID 0000-0002-3855-4194
Steven L KellySwansea University Medicine Health and Life Science, Swansea, Wales, United Kingdom.ORCID 0000-0001-7991-5040
David HessNevada State Public Health Laboratory, Reno, Nevada, USA.
Jeffrey M RybakSt Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID 0000-0002-9317-0935
Mark PandoriNevada State Public Health Laboratory, Reno, Nevada, USA.ORCID 0000-0003-0334-1946

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
Viral Genomics: evolution, spread, and host interactionsU19AI110818 · NIAID · BROAD INSTITUTE, INC. · PI EARL, ASHLEE MIRIAM · 2014 to 2024
$66.5M
Mapping the genomic and molecular mechanisms of antifungal resistance in the emerging fungal pathogen Candida aurisR01AI169066 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Christina A Cuomo, P. David Rogers · 2023 to 2026
$4.9M
CDC HHS 5 NU50CK000560-05-00Division of Intramural Research, National Institute of Allergy and Infectious Diseases U19AI110818NCI NIH HHS P30 CA021765NIAID NIH HHS R01 AI169066NIAID NIH HHS U19 AI110818
6 · The paper itself

Abstract

First identified in 2009,

Indexed as

Amphotericin BAntifungal AgentsCandida aurisDrug Resistance, FungalFungal ProteinsErgosterolFrameshift MutationHumansMicrobial Sensitivity TestsMutationWhole Genome SequencingAmphotericin BAntifungal AgentsErgosterolFungal Proteinsamphotericin BCandida aurisERG3geneticsmicrobialmultidrug resistancepublic health

Identifiers

PMID40980913
PMCPMC12587534

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.