Evidence map›Paper›PMID 40980907›Full record

ArticleAntimicrobial agents and chemotherapy2025

Molecular and pharmacodynamic insights into β-lactam therapy for high-inoculum

Ashlan J Kunz Coyne, Rachel Gray, Elizabeth May, Hunter Curry, Nicole Slain, Chris Delcher, Eugene Shin

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Ashlan J Kunz CoyneUniversity of Kentucky College of Pharmacy, Lexington, Kentucky, USA.ORCID 0000-0002-4891-8625
Rachel GrayUniversity of Kentucky College of Pharmacy, Lexington, Kentucky, USA.
Elizabeth MayUniversity of Kentucky College of Pharmacy, Lexington, Kentucky, USA.
Hunter CurryUniversity of Kentucky HealthCare, Lexington, Kentucky, USA.
Nicole SlainUniversity of Kentucky HealthCare, Lexington, Kentucky, USA.
Chris DelcherUniversity of Kentucky College of Pharmacy, Lexington, Kentucky, USA.
Eugene ShinUniversity of Kentucky College of Pharmacy, Lexington, Kentucky, USA.

Funding

Society of Infectious Diseases Pharmacists 3048116157
6 · The paper itself

Abstract

High-inoculum

Indexed as

Anti-Bacterial Agentsbeta-LactamsEnterobacter cloacaeEnterobacteriaceae InfectionsAzabicyclo Compoundsbeta-Lactamasesbeta-Lactam ResistanceBoronic AcidsCefepimeCeftazidimeCephalosporinsDrug CombinationsErtapenemHeterocyclic Compounds, 1-RingHumansMeropenemAnti-Bacterial Agentsavibactam, ceftazidime drug combinationAzabicyclo Compoundsbeta-Lactamasesbeta-LactamsBoronic AcidsCefepimeCeftazidimeCephalosporinsDrug CombinationsErtapenemHeterocyclic Compounds, 1-RingMeropenemmeropenem and vaborbactamThienamycinsvaborbactamAmpC-producing EnterobacteralesEnterobacter cloacae complexinoculum effectsimulated endocardial vegetation modelβ-lactamase expressionβ-lactam/β-lactamase inhibitors

Identifiers

PMID40980907
PMCPMC12587624

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.