Evidence map›Paper›PMID 40980883›Full record

ArticlemBio2025

Modulation of bacterial cell size and growth rate via activation of a cell envelope stress response.

Amanda Miguel, Matylda Zietek, Handuo Shi, Anna Sueki, Federico Corona, Lisa Maier, Jolanda Verheul, Tanneke den Blaauwen, David Van Valen, Athanasios Typas and 1 more

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. PreventingACS applied materials & interfaces · 2024
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Amanda Miguel *Department of Bioengineering, Stanford University, Stanford, California, USA.
Matylda Zietek *Genome Biology Unit, EMBL Heidelberg, Heidelberg, Germany.
Handuo Shi *Department of Bioengineering, Stanford University, Stanford, California, USA.
Anna SuekiGenome Biology Unit, EMBL Heidelberg, Heidelberg, Germany.
Federico CoronaGenome Biology Unit, EMBL Heidelberg, Heidelberg, Germany.
Lisa MaierGenome Biology Unit, EMBL Heidelberg, Heidelberg, Germany.
Jolanda VerheulFaculty of Natural Sciences, Mathematics, and Computer Science, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, the Netherlands.
Tanneke den BlaauwenFaculty of Natural Sciences, Mathematics, and Computer Science, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, the Netherlands.ORCID 0000-0002-5403-5597
David Van ValenDepartment of Bioengineering, Stanford University, Stanford, California, USA.
Athanasios TypasGenome Biology Unit, EMBL Heidelberg, Heidelberg, Germany.ORCID 0000-0002-0797-9018
Kerwyn Casey HuangDepartment of Bioengineering, Stanford University, Stanford, California, USA.ORCID 0000-0002-8043-8138

Funding

Engineering of cell shape and intracellular organizationDP2OD006466 · OD · STANFORD UNIVERSITY · PI HUANG, KERWYN C. · 2009 to 2009
$2.4M
National Science Foundation MCB-1149328, EF-2125383, IOS-2032985, PHYS-1066293NIH HHS DP2 OD006466
6 · The paper itself

Abstract

Cells mount elaborate responses to environmental stresses across multiple scales. In enterobacteria, the Rcs phosphorelay is activated by cell-envelope damage and by alterations to periplasmic thickness and cell width. To explore Rcs activation in the absence of external stresses IMPORTANCE: Bacteria must coordinate their growth rate, shape, and division to survive and flourish, yet how these cellular properties are maintained in the face of environmental stresses is poorly understood. Working with

Indexed as

Cell MembraneEscherichia coliEscherichia coli ProteinsStress, PhysiologicalBacterial ProteinsCell DivisionCytoskeletal ProteinsGene Expression Regulation, BacterialBacterial ProteinsCytoskeletal ProteinsEscherichia coli ProteinsFtsZ protein, BacteriarcsF protein, E coliA22cell divisioncell shapeFtsZgrowth rateRcs phosphorelay

Identifiers

PMID40980883
PMCPMC12607864

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.