ArticlemBio2025
TssW-PpkA-Fha axis controls the positioning and initiation of the type VI secretion system in
Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Gene-in-gene coding generates dual-isoform Fha condensates to control type VI secretion system assembly.Nature communications · 2026Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding how bacteria spatially regulate their molecular weaponry is key to unraveling their virulence and survival strategies in competitive ecosystems. The type VI secretion system (T6SS) is a highly potent contractile nanomachine that promotes bacterial survival by targeting competitors and hosts. While T6SS functionality has been extensively linked to the diversity of secreted effectors, the role of accessory components in spatially regulating its activity remains less understood. Here, we uncover that two membrane components, PpkA and TssW, are crucial modulators of T6SS efficacy in the plant pathogen IMPORTANCE: How cells determine where to assemble a macromolecular complex is a fundamental question in biology since the localization of these complexes is directly linked to functions. In bacteria, the type VI secretion system (T6SS) relies on effective positioning to target competitor and host cells in contact-dependent interactions. This study identifies a PpkA-TssW-Fha axis that orchestrates T6SS localization and activation through membrane anchoring and liquid-liquid phase separation at the inner membrane interface. These new insights can help us not only better understand how the T6SS functions but also better design T6SS-based solutions for therapeutic targeting of drug-resistant and T6SS-susceptible bacterial and fungal pathogens.
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Registered trials
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