Evidence map›Paper›PMID 40980878›Full record

ArticlemBio2025

Host cysteine proteases promote the severity of catheter-associated urinary tract infection and kidney fibrosis.

Wei Xu, Jian Chen, Lisa K McLellan, Ana L Flores-Mireles, David A Hunstad, Michael G Caparon

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. mBio · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wei XuDepartment of Molecular Microbiology, Washington University School of Medicine, Saint Louis, Missouri, USA.ORCID 0000-0003-4319-7432
Jian ChenDepartment of Genetics, Washington University School of Medicine, Saint Louis, Missouri, USA.
Lisa K McLellanDepartment of Pediatrics, Washington University School of Medicine, Saint Louis, Missouri, USA.ORCID 0000-0001-6418-8039
Ana L Flores-MirelesDepartment of Molecular Microbiology, Washington University School of Medicine, Saint Louis, Missouri, USA.ORCID 0000-0003-4610-4246
David A HunstadDepartment of Molecular Microbiology, Washington University School of Medicine, Saint Louis, Missouri, USA.ORCID 0000-0002-9848-0975
Michael G CaparonDepartment of Molecular Microbiology, Washington University School of Medicine, Saint Louis, Missouri, USA.ORCID 0000-0003-1171-0772

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Novel Catabolite Repression Pathway Controls Virulence in Streptococcus pyogenesR01AI070759 · NIAID · WASHINGTON UNIVERSITY · PI CAPARON, MICHAEL G. · 2007 to 2018
$3.4M
Understanding the role of catheter-associated protein deposition in the development of CAUTIR01DK128805 · NIDDK · UNIVERSITY OF NOTRE DAME · PI FLORES-MIRELES, ANA LIDIA, HOWELL, CAITLIN L · 2021 to 2025
$1.9M
EBPA-FIBROGEN INTERACTION IN ENTEROCOCCUS FAECALIS CAUTIR01AI108749 · NIAID · WASHINGTON UNIVERSITY · PI CAPARON, MICHAEL G. · 2014 to 2017
$1.5M
ANDROGEN INFLUENCE ON UTI SUSCEPTIBILITY AND SEVERITYR01DK111541 · NIDDK · WASHINGTON UNIVERSITY · PI HUNSTAD, DAVID · 2018 to 2021
$1.4M
National Science Foundation Graduate Research Fellowship Program DGE-1143954NCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA091842NIAID NIH HHS R01 AI070759NIAID NIH HHS R01 AI108749NIDDK NIH HHS R01 DK111541NIDDK NIH HHS R01 DK128805NIH HHS R01-DK111541
6 · The paper itself

Abstract

The bacterium IMPORTANCE: Catheter-associated urinary tract infections (CAUTIs) are the most prevalent healthcare-associated infection globally, with

Indexed as

Catheter-Related InfectionsCysteine ProteasesEnterococcus faecalisFibrosisKidneyUrinary Tract InfectionsAnimalsDisease Models, AnimalEosinophilsFemaleHumansMiceMice, Inbred C57BLCysteine Proteasescathepsinscatheter-associated urinary tract infection (CAUTI)cystene proteaseE64Enterococcus faecaliseosinophilsinflammationkidney fibrosis

Identifiers

PMID40980878
PMCPMC12607876

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.