Evidence map›Paper›PMID 40980811›Full record

ArticleFrontiers in physiology2025

Strength gains and distinct acute blood lactate responses induced by stepwise load reduction training in healthy males.

Zhuo Zeng, Chengyu Zhou, Wenhui Yin, Tao Chen, Te Han, Yongmin Xie, Aiguo Zhou

Abstract read
In one paragraph

Article in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhuo Zeng *School of Strength and Conditioning Training, Beijing Sport University, Beijing, China.
Chengyu Zhou *School of Strength and Conditioning Training, Beijing Sport University, Beijing, China.
Wenhui YinSchool of Social Sciences, Tsinghua University, Beijing, China.
Tao ChenSchool of Strength and Conditioning Training, Beijing Sport University, Beijing, China.
Te HanSchool of Strength and Conditioning Training, Beijing Sport University, Beijing, China.
Yongmin XieSchool of Strength and Conditioning Training, Beijing Sport University, Beijing, China.
Aiguo ZhouSchool of Strength and Conditioning Training, Beijing Sport University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: This study investigated whether stepwise load reduction training (SLRT) yields comparable or superior effects to medium load resistance training (MLRT) on one-repetition maximum (1RM) barbell back squat, thigh circumference (TC), muscle endurance (ME), counter movement jump (CMJ) performance, and acute blood lactate (BL) levels. Methods: Thirty healthy, physically active males completed both the SLRT and MLRT protocols in a crossover design to assess acute blood lactate responses firstly. Then they were randomly assigned to SLRT, MLRT, or control (CON) groups using a sealed envelope method for an 8 weeks intervention. Anthropometric data were collected at baseline. Performance metrics (1RM, TC, ME, and CMJ) were measured at baseline, week 4, and post intervention. Blinding was not feasible due to the visible nature of interventions. To minimize bias, testing was conducted by staff not involved in training, with standardized warm-ups and protocols applied across groups. Training volume, frequency and assessment timing were matched between SLRT and MLRT. Participants were instructed to avoid other structured training, and adherence was monitored weekly. Results: The results showed that both SLRT and MLRT significantly improved 1RM and ME, but SLRT produced greater gains. No significant differences were observed in TC. Additionally, SLRT led to significantly better CMJ performance and higher BL levels at immediate, 4th, 7th, and 9th minutes post exercise. The CON group performed significantly worse on all long-term outcomes compared to both SLRT and MLRT. While both SLRT and MLRT effectively enhance muscle strength, SLRT yields superior improvements in 1RM, ME, CMJ performance, and acute BL accumulation under equivalent training volumes. Discussion: These results suggest that SLRT may offer enhanced anaerobic conditioning benefits and superior adaptation potential. However, the findings should be interpreted with consideration of certain limitations, including the homogeneity of the sample and the relatively short intervention duration.

Indexed as

blood lactatedrop setsmedium loadmuscle strengthresistance trainingstepwise load reduction training

Identifiers

PMID40980811
PMCPMC12443800

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.