Evidence map›Paper›PMID 40980801›Full record

ReviewAllergologie select2025

Adrenaline nasal spray in emergency management: An initial expert opinion.

Regina Treudler, Knut Brockow, Kirsten Beyer, Ludger Klimek, Lars Lange, Sabine Schnadt, Johannes Ring, Margitta Worm

Abstract readReview
In one paragraph

Review in Allergologie select, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Regina TreudlerInstitute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin.
Knut BrockowDepartment of Dermatology and Allergology am Biederstein, Faculty of Medicine and Health, Technical University of Munich, Munich.
Kirsten BeyerDepartment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité Universitätsmedizin Berlin.
Ludger KlimekCenter for Rhinology and Allergology, Wiesbaden.
Lars LangeDepartment of Pediatrics and Adolescent Medicine, St. Marien-Hospital, Bonn.
Sabine SchnadtGerman Allergy and Asthma Association (DAAB). (DAAB), Mönchengladbach, and.
Johannes RingDepartment of Dermatology and Allergology am Biederstein, Faculty of Medicine and Health, Technical University of Munich, Munich.
Margitta WormDepartment of Dermatology, Venerology and Allergology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adrenaline is the drug of choice for the treatment of anaphylaxis. Up to now, intramuscular administration using an autoinjector has been recommended in national and international guidelines as the first-line treatment for anaphylaxis. Various adrenaline autoinjectors are available on the German market as emergency medication for immediate treatment by medical laypersons and specialists. Recently, a nasally administered adrenaline preparation was introduced for the first time and is available on the market. There are mainly data on healthy control subjects, which show a good adrenaline level and an expected effect on blood pressure and heart rate. To date, there is little clinical experience in the world literature for patients with anaphylaxis in children/adolescents and none in adults or from Germany. Therefore, we would like to discuss theoretically the use of adrenaline via the nasal route of administration in the care of anaphylaxis patients and compare it with the intramuscular administration of adrenaline autoinjectors.

Indexed as

adrenalineallergyanaphylaxisepinephrineexpert opinionintranasalnasal spray

Identifiers

PMID40980801
PMCPMC12444426

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.