Evidence map›Paper›PMID 40980752›Full record

ArticleArXiv2025

Inherited or produced? Inferring protein production kinetics when protein counts are shaped by a cell's division history.

Pedro Pessoa, Juan Andres Martinez, Vincent Vandenbroucke, Frank Delvigne, Steve Pressé

Abstract readPreprint
PubMed Full text at PMC
In one paragraph

Article in ArXiv, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Pedro PessoaCenter for Biological Physics, Arizona State University, Tempe, AZ, USA.
Juan Andres MartinezTerra Research and Teaching Centre, Microbial Processes and Interactions (MiPI), Gembloux Agro-Bio Tech, University of Liège, Gembloux, Belgium.
Vincent VandenbrouckeTerra Research and Teaching Centre, Microbial Processes and Interactions (MiPI), Gembloux Agro-Bio Tech, University of Liège, Gembloux, Belgium.
Frank DelvigneTerra Research and Teaching Centre, Microbial Processes and Interactions (MiPI), Gembloux Agro-Bio Tech, University of Liège, Gembloux, Belgium.
Steve PresséCenter for Biological Physics, Arizona State University, Tempe, AZ, USA.

Funding

Toward high spatiotemporal resolution models of single molecules for in vivo applicationsR35GM148237 · NIGMS · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI Steve Presse · 2023 to 2026
$1.7M
NIGMS NIH HHS R35 GM148237
6 · The paper itself

Abstract

Inferring protein production kinetics for dividing cells is complicated due to protein inheritance from the mother cell. For instance, fluorescence measurements - commonly used to assess gene activation - may reflect not only newly produced proteins but also those inherited through successive cell divisions. In such cases, observed protein levels in any given cell are shaped by its division history. As a case study, we examine activation of the

Indexed as

Bayesian inferenceCell cycleNeural NetworksNon-Markovian dynamical systemsProteomicsTranscriptional kinetics

Identifiers

PMID40980752
PMCPMC12447719

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.