Evidence map›Paper›PMID 40980716›Full record

ArticleEuropean heart journal open2025

Aortic valve-sparing root replacement and composite root replacement: a Danish multicentre nationwide study.

Emil Johannes Ravn, Lytfi Krasniqi, Viktor Poulsen, Poul Erik Mortensen, Bo Juel Kjeldsen, Jens Lund, Kristian Øvrehus, Oke Gerke, Rasmus Carter-Storch, Morten Holdgaard Smerup and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Emil Johannes RavnDepartment of Cardiothoracic Surgery, Odense University Hospital, Winsløwsvej 4, 5000 Odense C, Odense, Denmark.ORCID https://orcid.org/0000-0002-8992-5493
Lytfi KrasniqiDepartment of Cardiothoracic Surgery, Odense University Hospital, Winsløwsvej 4, 5000 Odense C, Odense, Denmark.ORCID https://orcid.org/0000-0002-8048-9779
Viktor PoulsenDepartment of Cardiothoracic Surgery, Odense University Hospital, Winsløwsvej 4, 5000 Odense C, Odense, Denmark.
Poul Erik MortensenDepartment of Cardiothoracic Surgery, Odense University Hospital, Winsløwsvej 4, 5000 Odense C, Odense, Denmark.
Bo Juel KjeldsenDepartment of Cardiothoracic Surgery, Odense University Hospital, Winsløwsvej 4, 5000 Odense C, Odense, Denmark.
Jens LundDepartment of Cardiothoracic Surgery, Odense University Hospital, Winsløwsvej 4, 5000 Odense C, Odense, Denmark.
Kristian ØvrehusDepartment of Cardiology, Odense University Hospital, J. B. Winsloewsvej 4, 5000 Odense C, Denmark.ORCID https://orcid.org/0000-0003-2454-5446
Oke GerkeDepartment of Clinical Research, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark.ORCID https://orcid.org/0000-0001-6335-3303
Rasmus Carter-StorchDepartment of Cardiology, Odense University Hospital, J. B. Winsloewsvej 4, 5000 Odense C, Denmark.ORCID https://orcid.org/0000-0002-0359-8728
Morten Holdgaard SmerupDepartment of Cardiothoracic Surgery, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Blegdamsvej 9, 2100 East Copenhagen, Denmark.
Ivy Susanne ModrauDepartment of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Palle Juul-Jensens Boulevard 69, 8200 Aarhus, Denmark.
Torsten Bloch RasmussenDepartment of Cardiology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 69, 8200 Aarhus, Denmark.
Katrine M MüllertzDepartment of Cardiology, Aalborg University Hospital, Hobrovej 18-22, 9000 Aalborg, Denmark.
Marie-Annick ClavelDepartment of Cardiology, Odense University Hospital, J. B. Winsloewsvej 4, 5000 Odense C, Denmark.ORCID https://orcid.org/0000-0002-8924-740X
Jordi Sanchez DahlDepartment of Cardiology, Odense University Hospital, J. B. Winsloewsvej 4, 5000 Odense C, Denmark.
Lars Peter Schødt RiberDepartment of Cardiothoracic Surgery, Odense University Hospital, Winsløwsvej 4, 5000 Odense C, Odense, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Aortic valve-sparing root replacement is recommended over composite root replacement for aortic root aneurysms, especially in younger patients, but long-term outcomes in low-volume nationwide settings remain unclear. The objectives are to compare long-term survival, stroke, and reoperation rates between the two procedures in a low-volume national setting. Methods and results: Patients were identified from the Western Danish Heart Registry and the Danish Heart Registry. Cases were validated by review of operative descriptions. The primary outcome was long-term survival from all-cause mortality; secondary outcomes included stroke, reoperation, recurrent aortic regurgitation, and aortic stenosis. Groups were balanced using propensity score matching. Echocardiographic data were provided for the matched cohort. We identified 760 patients treated with composite root replacement and 179 patients with aortic valve-sparing root replacement between January 2010 and April 2022. Mean follow-up was 6.5 years. Composite root replacement patients were younger [50.7 years (SD 14.1) vs. 55.2 (SD 13.5), Conclusion: In this nationwide study, aortic valve-sparing root replacement was associated with better long-term survival and lower stroke risk, supporting its role as a durable surgical option for selected patients.

Indexed as

Aortic root replacementAortic valve-sparing root replacementComposite root replacementLong-term outcomes

Identifiers

PMID40980716
PMCPMC12449084

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.