Evidence map›Paper›PMID 40980642›Full record

ArticleKidney international reports2025

Lower Podocyte Number per Glomerulus Associates With Progressive CKD.

Aleksandar Denic, Afsana A Shaik, Syed Khooshal Fareeduddin, Aperna Fnu, Mahesh Kumar, Aidan F Mullan, Vidit Sharma, Mariam P Alexander, Akhilesh Pandey, Roger C Wiggins and 3 more

Abstract read
In one paragraph

Article in Kidney international reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Beyond Hyperfiltration: Comprehensive Morphometric Assessment of Nephrons and Podocytes.Journal of the American Society of Nephrology : JASN · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Aleksandar DenicDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.
Afsana A ShaikDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.
Syed Khooshal FareeduddinDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.
Aperna FnuDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.
Mahesh KumarDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.
Aidan F MullanDivision of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, USA.
Vidit SharmaDepartment of Urology, Mayo Clinic, Rochester, Minnesota, USA.
Mariam P AlexanderDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Akhilesh PandeyDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Roger C WigginsDivision of Nephrology, University of Michigan, Ann Arbor, Michigan, USA.
Jeffrey B HodginDepartment of Pathology and Internal Medicine, Division of Nephrology, University of Michigan, Ann Arbor, Michigan, USA.
Stuart J ShanklandDivision of Nephrology, University of Washington, Seattle, Washington, USA.
Andrew D RuleDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.

Funding

The macro- and micro- anatomy and pathology of the aging kidneyR01DK090358 · NIDDK · MAYO CLINIC ROCHESTER · PI ANDREW David RULE · 2011 to 2026
$9.9M
NIDDK NIH HHS R01 DK090358
6 · The paper itself

Abstract

Introduction: Podocyte depletion may play an important role in chronic kidney disease (CKD); however, longitudinal clinical studies are lacking in populations without obesity-related glomerulopathy. Methods: Patients studied underwent radical nephrectomy for tumors between 2000 and 2021 and had < 10% interstitial fibrosis and tubular atrophy (IFTA) on histology. Cases who developed progressive CKD were identified by the onset of dialysis, kidney transplantation, sustained estimated glomerular filtration rate (eGFR) < 10 ml/min per 1.73 m Results: There were 35 CKD cases and 35 controls studied. Cases versus controls did not differ significantly by BMI (mean: 29.1 vs. 28.2 kg/m Conclusion: Low podocyte number per glomerulus is associated with the development of progressive CKD independent of CKD risk factors, kidney function, glomerular volume, and nephrosclerosis severity.

Indexed as

chronic kidney diseaseepidemiologyglomerulusparietal epithelial cellpodocytestereology

Identifiers

PMID40980642
PMCPMC12446936

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.