ArticleComprehensive psychoneuroendocrinology2025
Targeting concerns about falling to modulate biological stress systems: Effects of a multicomponent randomized controlled trial in older adults.
Article in Comprehensive psychoneuroendocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Reducing concerns about falling in older adults: evaluation of a multi-component intervention and the role of stress and inflammation markers - long-term effects of the FEARFALL randomized controlled trial.Aging clinical and experimental research · 2026Trial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Concerns about falling (CaF) are common in older adults and may act as a chronic stressor affecting physical activity, psychological well-being and physiological regulation. This study examined the impact of a 16-week multimodal exercise intervention on CaF, stress pathways, and peripheral inflammation in older adults. Methods: In the randomized, controlled FEARFALL study, 160 community-dwelling older adults (aged ≥70 years) were assigned to either an intervention group (IG) or a sham control group (SCG). The IG received a multimodal exercise program, while the SCG engaged in low-intensity activities. Three psychological questionnaires were used to assess CaF: Falls Efficacy Scale-International [FES-I] (fear of falling); Falls Efficacy Scale-International Avoidance Behavior [FES-IAB] (avoidance behavior); Updated Perceived Control of Falling Scale [UP-CoF] (perceived control). Hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system (SNS) activity was determined using saliva samples (cortisol, alpha-amylase), inflammatory markers using blood samples (C-reactive protein [CRP], Interleukin 6 [IL-6]). Results: There were significant improvements in CaF over time and perceived control in both groups (FES-I: Conclusion: A multimodal short-term intervention reduced psychological aspects of CaF, while physiological stress and inflammatory parameters may require more intensive or longer-term interventions. Findings support CaF as a biopsychosocial stressor and highlight the efficacy of multimodal programs in enhancing coping in older adults.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.