Evidence map›Paper›PMID 40980503›Full record

ArticleBioactive materials2025

Modulation of bone homeostasis by dual drug-loaded premixed magnesium tri-magnesium phosphate bone cement for the treatment of osteoporotic vertebral compression fractures.

Jiawei Liu, Jinjin Zhu, Takashi Goto, Shuhui Yang, Honglei Kang, Xiumei Wang, Honglian Dai

Erratum issuedAbstract read
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In one paragraph

Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Jiawei LiuState Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Hubei Key Discipline Laboratory of Orthopedic Tissue Injury and Repair, Wuhan University of Technology, Wuhan, 430070, China.
Jinjin ZhuDepartment of Orthopedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine & Zhejiang Key Laboratory of Mechanism Research and Precision Repair of Orthopaedic Trauma and Aging Diseases, Hangzhou, 310016, Zhejiang, China.
Takashi GotoNew Industry Creation Hatchery Center, Tohoku University, Sendai, 980-8579, Japan.
Shuhui YangDepartment of Orthopedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine & Zhejiang Key Laboratory of Mechanism Research and Precision Repair of Orthopaedic Trauma and Aging Diseases, Hangzhou, 310016, Zhejiang, China.
Honglei KangDepartment of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, China.
Xiumei WangState Key Laboratory of New Ceramics and Fine Processing, Key Laboratory of Advanced Materials of Ministry of Education, School of Materials Science and Engineering, Tsinghua University, Beijing, 100084, China.
Honglian DaiState Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Hubei Key Discipline Laboratory of Orthopedic Tissue Injury and Repair, Wuhan University of Technology, Wuhan, 430070, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoporotic vertebral compression fractures (OVCF) have emerged as a significant public health concern. Traditionally, poly(methyl methacrylate) (PMMA) has been utilized in clinical to treat OVCF. Nevertheless, its poor degradability, uncontrollable setting time, high curing temperatures, and the potential for cement leakage have limited their application. In addition, these bone cements required clinical handling, bringing inconvenience to surgery.This study developed a premixed magnesium phosphate bone cement loaded with strontium ranelate and bioglass microspheres grafted with alendronate sodium (pTMPC-SMA), to achieve regulation between osteogenesis and osteoclastogenesis on osteoporosis. The premixed cement offered storage stability, easy of use, anti-washout behavior, and sustained drug release properties. The in vivo osteoporotic rabbit vertebroplasty model demonstrated that pTMPC-SMA exhibited excellent cavity-filling adaptability, significantly enhanced new bone formation, and achieved superior osseointegration compared to the PMMA group. These findings demonstrate that pTMPC-SMA provides both excellent handling properties and osteogenic therapeutic advantages for treating osteoporosis-related bone defects.

Indexed as

Bone cementBone defectsBone homeostasisOsteoporosisVetebroplasty

Identifiers

PMID40980503
PMCPMC12448026

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.