Evidence map›Paper›PMID 40980439›Full record

ArticleNeuro-oncology advances

The role of palliative care at the time of stereotactic radiosurgery on healthcare utilization for frail patients with brain metastases.

Trent Kite, Teigan Dwyer, Charlotte Drury-Gworek, Tyson Barrett, John Herbst, Rachel Ombres, Leah Herbst, Stephen Karlovits, Rodney E Wegner, Matthew J Shepard

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In one paragraph

Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Trent KiteDepartment of Neurosurgery, Allegheny Health Network Neuroscience Institute, Pittsburgh, PA, USA.
Teigan DwyerEnterprise Analytics, Highmark Health, Pittsburgh, PA, USA.
Charlotte Drury-GworekEnterprise Analytics, Highmark Health, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0001-5084-3127
Tyson BarrettEnterprise Analytics, Highmark Health, Pittsburgh, PA, USA.
John HerbstDepartment of Neurosurgery, Allegheny Health Network Neuroscience Institute, Pittsburgh, PA, USA.
Rachel OmbresHighmark Health, Pittsburgh, PA, USA.
Leah HerbstDivision of Supportive Care, Allegheny Health Network Cancer Institute, Pittsburgh, PA, USA.
Stephen KarlovitsDivision of Radiation Oncology, Allegheny Health Network Cancer Institute, Pittsburgh, PA, USA.
Rodney E WegnerDivision of Radiation Oncology, Allegheny Health Network Cancer Institute, Pittsburgh, PA, USA.
Matthew J ShepardDepartment of Neurosurgery, Allegheny Health Network Neuroscience Institute, Pittsburgh, PA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The 5-factor modified frailty index (mFI-5) has been increasingly studied in the context of patients with central nervous system tumors. Previously, studies have demonstrated an inverse relationship between increasing mFI-5 scores and overall/progression-free survival in patients with brain metastases (BMs) undergoing stereotactic radiosurgery (SRS). Methods: A single payer insurance database was queried for patients undergoing SRS for BMs. Patients were stratified based on mFI-5 scores as follows: pre-frail (0-1), frail (2), and severely frail (≥ 3). Survival trends and healthcare utilization rates following treatment were analyzed across each frailty group. Results: A total of 9927 patients were retrospectively analyzed. Overall survival (OS) was significantly decreased in the frail and severely frail groups compared to pre-frail patients (frail: HR: 1.55, 95% CI: 1.33-1.80, Conclusion: Increasing frailty scores portended reduced OS with increased overall healthcare utilization rates. The introduction of palliative care prior to SRS decreased healthcare utilization rates across frailty cohorts.

Indexed as

brain metastasesfrailtypalliative carestereotactic radiosurgery

Identifiers

PMID40980439
PMCPMC12449133

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.