ArticleNeuro-oncology advances
Is tumor shape associated with molecular diagnosis, extent of resection, or postoperative focal deficits in diffuse low-grade gliomas?
Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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19 authors.
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Abstract
Background: This study aimed to explore the potential association between tumor shape, 1p/19q codeletion, EOR, and new postoperative focal deficits in patients with diffuse low-grade glioma. Methods: We analyzed data from 225 WHO grade 2 glioma surgeries performed in nine centers in Norway and Sweden. The tumor measurements were based on automatic segmentations of preoperative T2/FLAIR MRI scans by Raidionics. Contact surface area (CSA) was defined as the area between the tumor and brain parenchyma and was estimated by subtracting the surface area covered by the dura from the total surface area. The sphericity index (SI) was defined as the quotient of the tumor surface area and the surface area of a sphere with equal volume. Focal deficits were defined as any new motor, language, or visual deficits postoperatively. Results: The univariable analyses showed that a larger CSA was associated with higher age ( Conclusion: The tumor shape appears to be independently associated with EOR and new focal deficits but not with molecular diagnosis in patients with low-grade glioma.
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