ArticlePakistan journal of medical sciences2025
Clinical effectiveness of double-layer artificial dermis transplantation repairing hand wounds with limited bone and tendon exposure.
Article in Pakistan journal of medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Our objective was to investigate the clinical efficacy of double-layer artificial dermis transplantation in repairing hand wounds with limited bone and tendon exposure. Methods: This study involved 46 patients with limited bone and tendon exposure in the hand who were admitted to Dongguan Songshan Lake Central Hospital between January 2022 to January 2024. The patients were randomly divided into two groups: observation and control (N=23/group). The observation group underwent double-layer artificial dermis transplantation, whereas the control group received conventional treatment. The two groups were compared in terms of the overall wound condition, infection rate, granulation tissue growth time, wound healing time, pain scores, scar scores, and hand function recovery scores. Results: In the observation group, wound swelling and exudation were significantly reduced post-treatment, while no wound infections were observed. In contrast, the control group had significantly more severe wound swelling and exudation, with an infection rate of 13.04%. The observation group had shorter average times for granulation tissue growth and wound healing. Pain scores at days 3, 7, and 14, Vancouver Scar Scores (VSS) and Arm, Shoulder, and Hand Disability Scores (DASH) at six months were significantly lower in the observation group (P<0.05). Conclusion: The double-layer artificial dermis could effectively reduce the wound's inflammatory response, control infections, alleviate patient pain, accelerate granulation tissue growth and shorten the wound healing time. Furthermore, it could reduce scar tissue formation and restore the hand's functionality.
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