ArticleFrontiers in molecular neuroscience2025
Nfkbia-driven neuroinflammatory pathways mediate depression following spinal cord injury.
Article in Frontiers in molecular neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Neuroinflammation and depression: immune-brain interface mechanisms, biomarker stratification, and therapeutic strategies.Translational psychiatry · 2026Review
- Article
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6 authors.
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Abstract
Introduction: Spinal cord injury (SCI) frequently leads to severe motor impairments and psychological issues, particularly depression, which negatively affects overall quality of life. This study seeks to clarify the relationship between SCI and depression by employing a comprehensive approach that includes behavioral assessments, transcriptomic profiling, and molecular analyses. Methods: We established a weight-drop model of SCI and randomly assigned mice to Sham and SCI groups. Behavioral assessments included the Open Field Test (OP), Sucrose Preference Test (SP), and Tail Suspension Test (TS). We conducted transcriptomic analyses using datasets related to SCI and major depressive disorder (MDD) sourced from the GEO database. The hub gene, Results: Following SCI, mice displayed abnormal behaviors in the OP, SP, and TS, suggesting the development of depression-like symptoms. In light of these observations, we analyzed publicly available transcriptomic datasets related to SCI and depression, identifying 16 common differentially expressed genes. Functional enrichment analysis showed that these genes were primarily associated with biological processes linked to inflammatory responses. We constructed a protein-protein interaction network that highlighted four potential key genes ( Discussion: Our results suggest that neuroinflammation plays a crucial role in the onset of depression after SCI. This is supported by the activation of the IκB/p65 signaling pathway and the dysregulation of inflammatory cytokines. These findings align with clinical observations of mood disorders in patients with SCI and reflect known patterns of inflammatory cytokine dysregulation. This study underscores the significance of anti-inflammatory treatments and comprehensive neuropsychiatric management strategies in the rehabilitation of SCI patients.
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