Evidence map›Paper›PMID 40980293›Full record

ArticleWorld journal of diabetes2025

Targeting Ras homolog enriched in brain 1 to restore β-cell mass and function: A potential therapeutic strategy for diabetes.

Yao Peng, Dong-Dong Zhang, Ling Gan, Jia-Qi Zhang

Abstract readEditorial
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of diabetes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yao PengDepartment of Ultrasound Imaging, Postgraduate Union Training Base of Xiangyang No. 1 People's Hospital, School of Medicine, Wuhan University of Science and Technology, Xiangyang 441000, Hubei Province, China.
Dong-Dong ZhangDepartment of Oncology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang 441100, Hubei Province, China.
Ling GanDepartment of Ultrasound Imaging, Postgraduate Union Training Base of Xiangyang No. 1 People's Hospital, School of Medicine, Wuhan University of Science and Technology, Xiangyang 441000, Hubei Province, China.
Jia-Qi ZhangDepartment of Ultrasound Imaging, Postgraduate Union Training Base of Xiangyang No. 1 People's Hospital, School of Medicine, Wuhan University of Science and Technology, Xiangyang 441000, Hubei Province, China. 347235272@qq.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This editorial highlighted the central role of pancreatic β-cell dysfunction in the pathogenesis of diabetes mellitus and discussed the emerging significance of Ras homolog enriched in brain 1 (Rheb1) as a key regulator of β-cell mass and insulin-secretory capacity. While molecular mechanisms governing β-cell homeostasis remain incompletely defined, Yang

Indexed as

AMP-activated protein kinase pathwayDiabetes mellitusHepatocyte nuclear factor 4 alphaMechanistic target of rapamycin complex 1 pathwayRas homolog enriched in brain 1β cell dysfunction

Identifiers

PMID40980293
PMCPMC12444310

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.