ArticleFrontiers in cardiovascular medicine2025
A prediction model of superimposed preeclampsia in women with chronic hypertension.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Pre-Eclampsia-Induced Maternal Liver Dysfunction: Systematic Review, Meta-Analysis and Meta-Regression of Observation Studies.Life (Basel, Switzerland) · 2026Review
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6 authors.
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Abstract
Objective: The incidence of chronic hypertension (CH) with superimposed preeclampsia (PE) is 5-6 times higher than that in non-CH pregnancies, with earlier onset, higher rates of multi-organ dysfunction, and poorer maternal/fetal outcomes, yet lacks dedicated screening tools. The purpose of this study is to establish and validate a prediction model for CH with superimposed PE. Methods: A retrospective case-control study was conducted on 471 CH patients admitted to the Tongzhou Maternal and Child Health Care Hospital of Beijing from January 2020 to December 2023. The patients were divided into superimposed preeclampsia (SPE) group (161 cases) and non-preeclampsia (NPE) group (310 cases) based on whether they had complicated PE. The patients were randomly divided into training set and validation set in a 7:3 ratio. General and clinical data were collected, and single-and multi-factor logistic regression analysis were used to screen for independent factors affecting PE in the training set. Based on the screening results, the diagnostic efficacy of PE was evaluated using the receiver operating characteristic curve. Risk prediction nomogram model was constructed using R language. The Bootstrap method was used to validate and produce calibration plots; the decision curve analysis (DCA) was used to assess the clinical benefit rate of the model. Results: The results of single factor and further multi-factor analysis showed that peripheral blood levels of direct bilirubin (DBIL), gamma-glutamyl transferase (GGT), glucose (GLU), cystatin-C (CysC) and pre-pregnancy body mass index (BMI) were independent influences on the occurrence of PE ( Conclusions: The occurrence of PE in women with CH is related to the peripheral blood levels of DBIL, GGT, GLU, CysC and pre-pregnancy BMI, and the combination of these indexes has a better clinical diagnostic value than a single index. The nomogram model constructed by using the above indicators can be used for the prediction of PE and has high predictive efficacy.
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