ArticleFrontiers in cardiovascular medicine2025
The λ pattern on time-RR interval scatter plot of neonatal ambulatory ECG: a marker of transient bradycardia.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Neonatal bradycardia often triggers transient escape rhythms that challenge clinical diagnosis, with current methods lacking dynamic biomarkers for risk stratification. Objective: To validate the λ pattern, a heart rate dynamic signature on time-RR interval scatter plot, for distinguishing escape rhythms from transient sinus bradycardia and predicting recovery timelines in neonates. Methods: Retrospective analysis of 36 neonates (≤28 days) with 24 h electrocardiogram (ECG) monitoring. Holter data identified λ patterns (abrupt ≥20% RR prolongation and >3 s gradual recovery). Reverse-engineering ECG validated rhythm origins. Survival models assessed λ burden-prognosis correlations. Results: 487 λ patterns (15.5 ± 3.2/neonate) were detected: 80.3% escape rhythms, 19.7% sinus bradycardia. High λ burden (≥21/24 h) predicted delayed recovery vs. low burden (≤10/24 h) [HR = 4.22 (95% CI: 1.98-9.01), Conclusion: The λ pattern shows promise as a noninvasive biomarker for stratifying neonatal bradycardia and shows potential to guide recovery timeline prediction. Integration of this approach could optimize neonatal arrhythmia management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.