Evidence map›Paper›PMID 40980140›Full record

ArticleClinical, cosmetic and investigational dermatology2025

Anti-MDA5 Positive Dermatomyositis Overlapping with Rheumatoid Arthritis: A Case Report.

Fuzhen Yuan, Zhenhua Huang, Eryao Zhang, Dingye Yao, Junsheng Sun

Abstract readCase Reports
In one paragraph

Article in Clinical, cosmetic and investigational dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fuzhen Yuan *Department of General Practice, Longgang District Central Hospital of Shenzhen, Shenzhen, 518116, People's Republic of China.
Zhenhua Huang *Department of General Practice, Longgang District Central Hospital of Shenzhen, Shenzhen, 518116, People's Republic of China.
Eryao ZhangDepartment of General Practice, Longgang District Central Hospital of Shenzhen, Shenzhen, 518116, People's Republic of China.
Dingye YaoDepartment of General Practice, Longgang District Central Hospital of Shenzhen, Shenzhen, 518116, People's Republic of China.
Junsheng SunDepartment of General Practice, Longgang District Central Hospital of Shenzhen, Shenzhen, 518116, People's Republic of China.ORCID 0009-0002-3593-122X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a rare case of overlap syndrome between anti-MDA5-positive dermatomyositis (DM) and rheumatoid arthritis (RA) in a 65-year-old woman. Initially diagnosed with RA, the patient later developed characteristic DM manifestations including characteristic DM rash, generalized weakness, poor appetite, and unintentional weight loss. Laboratory findings revealed elevated muscle enzymes, positive anti-melanoma differentiation-associated gene 5 (MDA5) antibody and anti-Ro52 antibodies, and increased anti-citrullinated protein antibodies. The patient showed significant improvement following combination therapy with prednisone and mycophenolate mofetil, highlighting the importance of early recognition and appropriate management of this rare overlap syndrome.

Indexed as

anti-MDA5 antibodiesdermatomyositisinterstitial lung diseaseoverlap syndromerheumatoid arthritis

Identifiers

PMID40980140
PMCPMC12447974

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.