Evidence map›Paper›PMID 40980063›Full record

ArticlePeerJ2025

Comparison of the antibacterial properties of peptides from the hepatopancreas of red king crab and snow crab and development of an approach for red king crab peptide isolation from the hepatopancreas.

Vladislav Molchanov, Alfiya Yunusova, Olesya Kazantseva, Alexander Yegorov, Alexander Lukin, Alexander Timchenko, Vitaly Novikov, Nikolay Novojilov, Maria Timchenko

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Vladislav MolchanovLaboratory of NMR Biosystems, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia.
Alfiya YunusovaLaboratory for Cell Engineering, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia.
Olesya KazantsevaLaboratory of Bacteriophage Biology, GK Skryabin Institute of Biochemistry and Physiology of Microorganisms, Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences, Federal Research Center Pushchino, Pushchino, Moscow Region, Russia.
Alexander YegorovLaboratory of NMR Biosystems, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia.
Alexander LukinGroup of Applied Enzymology, Institute for Biological Instrumentation, Federal Research Center "Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences", Pushchino, Moscow Region, Russia.
Alexander TimchenkoGroup of Experimental Research and Engineering Oligomeric Structures, Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow Region, Russia.
Vitaly NovikovPolar Branch of Russian Federal Research Institute of Fisheries and Oceanography, Murmansk, Russia.
Nikolay NovojilovMM Shemyakin and Yu A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Maria TimchenkoLaboratory of NMR Biosystems, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The hepatopancreas of crustaceans is an important immune organ involved in the secretion of immune effectors such as antimicrobial peptides. Crustacean antimicrobial peptides are very diverse and have a broad spectrum of activity, but are poorly explored. In this work, the activity of antibacterial peptides from the hepatopancreas of red king crab and snow crab was compared. Both peptides were found to be highly effective in inhibiting the growth of gram-positive bacteria. At the same time, the peptide from the red king crab was found to be highly sensitive to the presence of salt and a disulfide bond reducing agent, in contrast to the peptide from the snow crab. An approach for the chromatographic purification of the red king crab peptide from the hepatopancreas was developed. Both peptides are of interest for the development of novel antibacterial drugs.

Indexed as

AnomuraAnti-Bacterial AgentsAntimicrobial PeptidesBrachyuraHepatopancreasPeptidesAnimalsGram-Positive BacteriaMicrobial Sensitivity TestsAnti-Bacterial AgentsAntimicrobial PeptidesPeptidesAntimicrobial peptidesHepatopancreasRed King crabSnow crab

Identifiers

PMID40980063
PMCPMC12447949

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.