Evidence map›Paper›PMID 40980022›Full record

ArticleOphthalmology science

Pointwise Structure-Function Analysis of the Ellipsoid Zone in Retinitis Pigmentosa Using an Artificial Intelligence-Assisted OCT and Microperimetry Overlay.

Jesse A Most, An D Le, Melanie D Tran, Evan H Walker, Aneesh Swamy, Dirk-Uwe G Bartsch, William R Freeman, Truong Nguyen, Cheolhong An, Shyamanga Borooah

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmology science. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jesse A MostJacobs Retina Center, Shiley Eye Institute, University of California San Diego, La Jolla, California.
An D LeDepartment of Electrical and Computer Engineering, University of California San Diego, La Jolla, California.
Melanie D TranJacobs Retina Center, Shiley Eye Institute, University of California San Diego, La Jolla, California.
Evan H WalkerViterbi Family Department of Ophthalmology and Shiley Eye Institute, University of California San Diego, La Jolla, California.
Aneesh SwamyUniversity of California San Diego, La Jolla, California.
Dirk-Uwe G BartschJacobs Retina Center, Shiley Eye Institute, University of California San Diego, La Jolla, California.
William R FreemanJacobs Retina Center, Shiley Eye Institute, University of California San Diego, La Jolla, California.
Truong NguyenDepartment of Electrical and Computer Engineering, University of California San Diego, La Jolla, California.
Cheolhong AnDepartment of Electrical and Computer Engineering, University of California San Diego, La Jolla, California.
Shyamanga BorooahJacobs Retina Center, Shiley Eye Institute, University of California San Diego, La Jolla, California.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To perform a pointwise structure-function analysis of the ellipsoid zone (EZ) in retinitis pigmentosa (RP) using an artificial intelligence-based overlay to understand EZ structure-function relationships. Design: A single-center retrospective study. Subjects: Patients with clinically confirmed RP. Methods: Same-day spectral-domain OCT (SD-OCT) and microperimetry near-infrared images were overlaid in patients with confirmed RP. Overlay used a coarse alignment artificial intelligence model. Each locus, on a 68-point microperimetry grid spanning the central 20° of the macula, was identified on individual SD-OCT B-scans. Ellipsoid zone structure was graded at each locus on a 3-point scale: grade 0 = EZ not visible; grade 1 = EZ attenuated; grade 2 = EZ normal. Ellipsoid zone grades were correlated with microperimetry sensitivity scores recorded in decibels (dB). Main Outcome Measures: Correlation of EZ integrity on SD-OCT with microperimetric retinal sensitivity. Results: Fifty-one eyes from thirty-one patients with RP were included in the analysis, with 60 total overlays, including follow-up studies, resulting in 3985 test loci being graded. Patients had a mean age of 39.4 (32.8-46.0) years, with 41.9% being female. Mean best-corrected visual acuity was 0.166 (0.129-0.203) logarithm of the minimum angle of resolution. The overall mean sensitivity (MS) was 9.72 (7.32-12.12) dB, whereas MS was 6.02 (4.06-7.98) dB for grade 0 loci, 18.36 (16.35-20.36) dB for grade 1 loci, and 20.90 (18.87-22.93) dB for grade 2 loci. Differences in MS were significant between graded groups ( Conclusions: We identified local EZ structure-function incongruencies in RP using a pointwise analysis of structure-function overlay. These loci of interest may be overlooked in analyses that average across the visual field. Preserved photoreceptor function, in the absence of visibly intact EZ, warrants further investigation. Financial Disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Indexed as

Ellipsoid zoneRetinitis pigmentosaSpectral domain optical coherence tomographyStructure–function

Identifiers

PMID40980022
PMCPMC12446769

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.