Evidence map›Paper›PMID 40979947›Full record

ArticleSexual medicine2025

Evaluating a non-pharmacological treatment for primary premature ejaculation patients with low sexual frequency: a retrospective study on vacuum negative pressure hydropneumatic/pneumatic bubble massage.

Qing-Qiang Gao, Chao-Ba He, Bin Wang, Yu-Tian Dai, Bai-Bing Yang, Xiao-Zhi Zhao

Abstract read
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Article in Sexual medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Qing-Qiang GaoDepartment of Andrology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, China.
Chao-Ba HeDepartment of Andrology, Guangdong Hospital of Traditional Chinese Medicine, Zhuhai, 519015, China.
Bin WangDepartment of Andrology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, China.
Yu-Tian DaiDepartment of Andrology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, China.
Bai-Bing YangDepartment of Andrology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, China.ORCID https://orcid.org/0000-0002-5821-3741
Xiao-Zhi ZhaoDepartment of Andrology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Premature ejaculation (PE) is a common male sexual dysfunction with treatment limitations including side effects and partner dependency. Aim: To evaluate vacuum negative pressure hydropneumatic/pneumatic bubble massage (VNPHP/PBM) efficacy in primary PE (PPE) patients stratified by sexual frequency, focusing on subjective low-frequency (avoidance due to PE) vs objective low-frequency subgroups. Methods: Retrospective analysis of 42 PPE patients: 22 low-frequency (LF; <4 intercourse/month) including 13 subjective (sub-LF) and 9 objective (ob-LF) vs 20 non-low-frequency (NLF; ≥4/month). Outcomes: Primary: intravaginal ejaculation latency time (IELT); secondary: Premature Ejaculation Diagnostic Tool (PEDT), Self-Rating Anxiety Scale (SAS) scores, and sexual frequency changes at 4 weeks. Results: Both groups showed significant improvements in IELT, PEDT, and SAS scores ( Clinical implications: Vacuum negative pressure hydropneumatic/pneumatic bubble massage is a partner-independent therapy that not only improves ejaculatory control but also restores sexual activity in patients avoiding intercourse due to PE-related anxiety. Strengths and limitations: Strengths: First study analyzing subjective vs objective low-frequency PE, standardized protocols. Limitations: Retrospective design, self-reported IELT data, lack of a control group, and the non-blinded nature of the study. Conclusion: Vacuum negative pressure hydropneumatic/pneumatic bubble massage significantly improves PE symptoms with amplified benefits in low-frequency patients, particularly those with PE-driven sexual avoidance.

Indexed as

intravaginal ejaculation latency timelow-frequencypremature ejaculationvacuum negative pressure hydropneumatic/pneumatic bubble massage

Identifiers

PMID40979947
PMCPMC12448630

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.