ArticleCrohn's & colitis 3602025
Outcomes of Outpatient Advanced Therapy Exposed Patients Hospitalized With Severe Ulcerative Colitis.
Article in Crohn's & colitis 360, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Real-world patient characteristics, treatments, and outcomes during and after severe ulcerative colitis hospitalization.Journal of Crohn's & colitis · 2026Article
- Previous Exposure to Advanced Therapies in Acute Severe Ulcerative Colitis: A New Risk Factor for Colectomy?Crohn's & colitis 360 · 2025Article
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Authors and funding
7 authors.
Funding
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Abstract
Background: Contemporary characteristics of hospitalized patients with ulcerative colitis (UC) may differ from historic standards in terms of prior drug exposure and disease severity. The impact of these differences on outcomes is unclear. This study aimed to assess inpatient UC outcomes according to prior outpatient drug exposure and measures of disease severity. Methods: This was a multicenter, retrospective study of adult patients (age ≥ 18 years) hospitalized for severe UC. The primary outcome was the colectomy rate among outpatient advanced therapy exposed (ATE) vs advanced therapy naïve (ATN) patients. Secondary outcomes included length of hospitalization and need for rescue medical therapy. Results: A total of 370 patients were included with 86 (23%) in the ATE group and 284 (77%) in the ATN group. In the ATE group, 21 patients (25%) required colectomy vs 26 (9%) in the ATN group ( Conclusions: Outpatient ATE was associated with an increased risk of colectomy among hospitalized patients with severe UC. On multivariable analysis, low albumin was independently associated with the risk of colectomy. This suggests that higher colectomy rates observed in ATE patients may reflect underlying differences in disease severity.
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