Evidence map›Paper›PMID 40979830›Full record

ArticleRegenerative biomaterials2025

Mechanically reinforced core-shell scaffold with integrated structure and function for accelerated tendon repair.

Xiaoxi Long, Yanzhao Dong, Ting Guo, Yiting Zhang, Peng Liu, Yongpeng Wu, Hui Lu, Xianwei Wang, Hemin Nie, Swee Hin Teoh and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Beyond labeling: differential AcRegenerative biomaterials · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiaoxi LongCollege of Materials Science and Engineering, College of Biology, Hunan University, Changsha 410082, China.
Yanzhao DongDepartment of Orthopedics, The First Affiliated Hospital of Zhejiang University, Hangzhou 310003, China.
Ting GuoCollege of Materials Science and Engineering, College of Biology, Hunan University, Changsha 410082, China.
Yiting ZhangCollege of Materials Science and Engineering, College of Biology, Hunan University, Changsha 410082, China.
Peng LiuCollege of Materials Science and Engineering, College of Biology, Hunan University, Changsha 410082, China.
Yongpeng WuCollege of Materials Science and Engineering, College of Biology, Hunan University, Changsha 410082, China.
Hui LuDepartment of Orthopedics, The First Affiliated Hospital of Zhejiang University, Hangzhou 310003, China.
Xianwei WangDepartment of Vascular Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Hemin NieCollege of Materials Science and Engineering, College of Biology, Hunan University, Changsha 410082, China.
Swee Hin TeohCollege of Materials Science and Engineering, College of Biology, Hunan University, Changsha 410082, China.
Feng WenZhejiang Engineering Research Centre for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, China.ORCID https://orcid.org/0000-0002-7130-6846
Zuyong WangCollege of Materials Science and Engineering, College of Biology, Hunan University, Changsha 410082, China.ORCID https://orcid.org/0000-0003-0136-6402

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Core-shell scaffold designs that mimic the biophysical structure of tendon extracellular matrix offer unique advantages for tendon repair. However, balancing the structural integrity of the scaffold with the desired material and biological properties remains challenging, limiting the effectiveness of the scaffold. Here, we present a new method for fabricating a core-shell scaffold with tailored properties for tendon tissue engineering. The scaffold core, designed for cell guidance, was created using direct ink writing, resulting in a helically interconnected fibre structure with controllable anisotropy and pore sizes. The mechanically reinforced shell, produced through uniaxial cold stretching of a laser-drilled sheet, featured microsurface ridges and through-hole arrays. The core-shell integration enabled sequential degradation and mechanical properties aligned with tendon tissue requirements, providing extended structural support and improved space for neotissue ingrowth.

Indexed as

core-shell structurescaffoldtendontissue engineering

Identifiers

PMID40979830
PMCPMC12448295

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.