Evidence map›Paper›PMID 40979828›Full record

ArticleRegenerative biomaterials2025

Plasma-derived mitochondrial transplantation attenuates paraspinal muscle atrophy following spinal surgery.

Ikhyun Lim, Seong-Hoon Kim, Mi Jin Kim, Chang-Koo Yun, Kyunghoon Min, Yong-Soo Choi

Abstract read
In one paragraph

Article in Regenerative biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ikhyun LimDepartment of Bioconvergence Science, Graduate School, CHA University, Seongnam 13488, Republic of Korea.ORCID https://orcid.org/0000-0001-9088-2577
Seong-Hoon KimDepartment of Bioconvergence Science, Graduate School, CHA University, Seongnam 13488, Republic of Korea.
Mi Jin KimDepartment of Biotechnology, CHA University, Seongnam 13488, Republic of Korea.
Chang-Koo YunDepartment of Biotechnology, CHA University, Seongnam 13488, Republic of Korea.ORCID https://orcid.org/0000-0002-2179-2794
Kyunghoon MinDepartment of Rehabilitation Medicine, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam 13496, Republic of Korea.
Yong-Soo ChoiDepartment of Bioconvergence Science, Graduate School, CHA University, Seongnam 13488, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Paraspinal muscle atrophy (PMA) is a common complication after spinal surgery, often leading to reduced spinal stability and prolonged discomfort. While mitochondrial dysfunction has emerged as a key contributor to PMA, existing therapies do not adequately address this underlying pathophysiology. In this study, we investigated the regenerative potential of plasma-derived mitochondria (pMT) as a cell-free and autologous biomaterial to mitigate PMA. Mitochondria were isolated from human peripheral blood and confirmed to maintain their structural integrity and respiratory activity. In an

Indexed as

laminectomymitochondrial transplantationmuscle regenerationparaspinal muscle atrophyplasma-derived mitochondria

Identifiers

PMID40979828
PMCPMC12449618

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.