Evidence map›Paper›PMID 40979827›Full record

ArticleRegenerative biomaterials2025

PMMA bone cement with AgNP@CDs nanocomposite for infection control and inflammation mitigation.

Ihsan Ullah, Jian Ju, Yapei Song, Siyi Chen, Mengshi Chen, Siran Wang, Wenzhen Zhang, Wenhui Chen, Zhifeng You, Huaqiong Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ihsan UllahJoint Research Centre on Medicine, The Affiliated Xiangshan Hospital of Wenzhou Medical University, Ningbo, Zhejiang 315700, China.
Jian JuZhejiang Engineering Research Centre for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325001, China.
Yapei SongPostgraduate Training Base Alliance of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Siyi ChenZhejiang Top-Medical Medical Dressing Co. Ltd, Wenzhou, Zhejiang 325025, China.
Mengshi ChenKey Laboratory of Biomaterials and Biofabrication for Tissue Engineering, Gannan Medical University, Ganzhou, Jiangxi 341000, China.
Siran WangZhejiang Engineering Research Centre for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325001, China.
Wenzhen ZhangThe Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Wenhui ChenYuhuan People's Hospital, Taizhou, Zhejiang 317600, China.
Zhifeng YouZhejiang Engineering Research Centre for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325001, China.ORCID https://orcid.org/0000-0002-8983-5041
Huaqiong LiJoint Research Centre on Medicine, The Affiliated Xiangshan Hospital of Wenzhou Medical University, Ningbo, Zhejiang 315700, China.ORCID https://orcid.org/0000-0002-6151-6479
Feng WenPostgraduate Training Base Alliance of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.ORCID https://orcid.org/0000-0002-7130-6846
Wei ZuoJoint Research Centre on Medicine, The Affiliated Xiangshan Hospital of Wenzhou Medical University, Ningbo, Zhejiang 315700, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bioinert poly(methyl methacrylate) (PMMA) is widely employed as a bone cement material in orthopedic and trauma surgery applications; however, its susceptibility to bacterial infection and bioinert nature limits its clinical applications. In this study, we developed a PMMA-based bone cement incorporating a silver nanoparticle-carbon dots (AgNP@CDs) nanocomposite (∼70 nm) at concentrations (2 wt%) with a Young's modulus (324.74 ± 7.08 MPa) to simultaneously combat bacterial infections, minimize cytotoxicity and support tissue regeneration. The CDs stabilize and functionalize AgNPs, improving their dispersion and bioavailability while enabling the controlled and sustained release of antimicrobial ions through incorporation with bone cement. The antibacterial efficacy of the composite was thoroughly evaluated, revealing its ability to disrupt bacterial cell membranes, generate reactive oxygen species and inhibit bacterial growth. These mechanisms collectively contribute to a significant reduction in bacterial growth of up to ∼90% in both

Indexed as

antimicrobialbacterial infectionbiocompatibilitybone cementnanocomposite

Identifiers

PMID40979827
PMCPMC12448944

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.