Low Bone Mass in Probable CD1a-negative Langerhans Cell Histiocytosis: A Diagnostic Challenge.

Rim Masri, Hussein Mokdad, Nermine Gherbewe, Batoul Raad, Zeinab Ali Issa

Abstract readCase Reports

In one paragraph

Article in JCEM case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rim MasriDepartment of Endocrinology, Faculty of Medical Sciences, Lebanese University, Hadath P.O. Box 3, Lebanon.ORCID https://orcid.org/0009-0001-9106-395X

Hussein MokdadDepartment of Internal Medicine, Faculty of Medical Sciences, Lebanese University, Hadath P.O. Box 3, Lebanon.

Nermine GherbeweDepartment of Internal Medicine, Faculty of Medical Sciences, Lebanese University, Hadath P.O. Box 3, Lebanon.

Batoul RaadDepartment of Neurosurgery, Faculty of Medical Sciences, Lebanese University, Hadath P.O. Box 3, Lebanon.

Zeinab Ali IssaDepartment of Endocrinology, Faculty of Medical Sciences, Lebanese University, Hadath P.O. Box 3, Lebanon.ORCID https://orcid.org/0009-0000-0174-7454

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Langerhans cell histiocytosis (LCH) is a rare disease characterized by CD1a/CD207-positive dendritic cells. This report presents a probable CD1a-negative LCH case in a 21-year-old man with chronic neck pain, low bone mass, and vertebra plana at the C6 level. Over 2 years, his symptoms progressed to severe vertebral collapse. Imaging and biopsy excluded malignancy and infection. Histopathology revealed a mixed immune infiltrate without CD1a expression, complicating diagnosis. LCH was confirmed through clinicoradiological correlation and exclusion of other disorders. Management included surgical stabilization and bisphosphonate therapy. This is the fourth reported CD1a-negative LCH case and the first associated with early-onset low bone mass for age. This case highlights diagnostic challenges and the importance of a multidisciplinary approach.

Indexed as

bone lesionsCD1a-negativeLangerhans cell histiocytosislow bone mass for agevertebra planayoung adult

Identifiers

PMID40979825

DOI10.1210/jcemcr/luaf211

PMCPMC12448924

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