Evidence map›Paper›PMID 40979824›Full record

ArticleJCEM case reports2025

A Misleading Neck Mass: Branchial Cleft Cyst Mimicking Anaplastic Thyroid Carcinoma.

Taylor L Jamil, Ryan Thomas, Christie G Turin, Brian P Cervenka, Nikita Pozdeyev

Abstract readCase Reports
In one paragraph

Article in JCEM case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Taylor L JamilDepartment of Otolaryngology, University of Colorado School of Medicine, Aurora, CO 80045, USA.ORCID https://orcid.org/0009-0004-8117-5714
Ryan ThomasDepartment of Pathology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Christie G TurinDivision of Endocrinology, Diabetes, and Metabolism, University of Colorado School of Medicine, Aurora, CO 80045, USA.ORCID https://orcid.org/0000-0002-1336-7149
Brian P CervenkaDepartment of Otolaryngology, University of Colorado School of Medicine, Aurora, CO 80045, USA.ORCID https://orcid.org/0000-0003-0747-3161
Nikita PozdeyevDivision of Endocrinology, Diabetes, and Metabolism, University of Colorado School of Medicine, Aurora, CO 80045, USA.ORCID https://orcid.org/0000-0001-8574-1972

Funding

Colorado Clinician Scientist Training ProgramR25DC021948 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI Yuri Agrawal, Sue C. Kinnamon · 2024 to 2026
$498k
NIDCD NIH HHS R25 DC021948
6 · The paper itself

Abstract

A 33-year-old female individual had a history of a lymph node excision positive for metastatic papillary thyroid carcinoma (PTC) in 2016. She was treated with a total thyroidectomy and central neck dissection showing 0.2-cm micro-PTC without paratracheal lymph node involvement, followed by adjuvant radioactive iodine treatment with 104 mCi of iodine-131. After 9 years without evidence of disease, she presented with a mildly tender, firm, left neck level II mass rapidly enlarging over 3 weeks. Neck ultrasound revealed a 3.5 cm irregular hypoechoic mass with internal vascularity and punctate echogenic foci. A fine needle biopsy showed inflammatory and mature squamous cells with elevated thyroglobulin but no definitive evidence of malignancy. The patient was scheduled for urgent neck dissection; however, just a left lymph node excision was performed as intraoperative frozen pathology showed no cancer. Surgical histopathology showed branchial cleft cyst tissue. The most concerning diagnosis for a rapidly enlarging neck mass in an adult with a history of metastatic PTC is anaplastic thyroid carcinoma. However, other diagnoses such as branchial cleft anomalies, lymphoma, or non-thyroid metastatic malignancies should be considered. Intraoperative frozen section pathology is crucial to direct surgical management of an unknown neck mass concerning for anaplastic thyroid cancer.

Indexed as

anaplastic thyroid cancerbranchial cleft cystlymph node dissectionneck mass

Identifiers

PMID40979824
PMCPMC12449159

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.